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Only the spleen, and not the bone marrow, of such NK\u2010depleted mice shows an increase in the number of myeloid precursur cells able to form colonies in soft agar as compared to control mice with normal levels of NK activity. The increase in number of hematopoietic immature cells due to lack of a regulatory cell <jats:italic>(i.e.<\/jats:italic> NK cell) is selective for the committed myeloid precursur cells, and not evident for erythroid or pluripotent progenitor cells. This is direct evidence in support of the hypothesis that NK cells in the autologous host serve as a regulator of extramedullary myelopoiesis.<\/jats:p>","DOI":"10.1002\/eji.1830180326","type":"journal-article","created":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T01:15:11Z","timestamp":1172711711000},"page":"485-488","source":"Crossref","is-referenced-by-count":26,"title":["In vivo function of natural killer cells as regulators of myeloid precursor cells in the spleen"],"prefix":"10.1002","volume":"18","author":[{"given":"Mona","family":"Hansson","sequence":"first","affiliation":[]},{"given":"Max","family":"Petersson","sequence":"additional","affiliation":[]},{"given":"Gloria C.","family":"Koo","sequence":"additional","affiliation":[]},{"given":"Hans","family":"Wigzell","sequence":"additional","affiliation":[]},{"given":"Rolf","family":"Kiessling","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2005,11,22]]},"reference":[{"key":"e_1_2_1_2_2","volume-title":"NK Cells and Other Natural Effector Cells","author":"Herberman R. 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