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In contrast, oligodendrocytes, another type of macroglia, cannot be induced to express Ia. The astrocytes which have been shown to express Ia are from a particular glial lineage and are called type\u20101 astrocytes. The oligodendrocyte\u2010type\u20102 astrocyte (0\u20102A) lineage, which gives rise to oligodendrocytes, also gives rise to a second class of astrocytes called type\u20102 astrocytes and the ability of type\u20102 astrocytes or the common O\u20102A progenitor cell to express Ia is not known. We have now found that both type\u20102 astrocytes and O\u20102A progenitor cells can be induced to express Ia by IFN\u2010<jats:sub>\u0393<\/jats:sub> but Ia expression is not induced in oligodendrocytes in parallel cultures. Thus, it appears that differentiation of O\u20102A progenitor cells into oligodendrocytes is specifically associated with a loss of inducibility of Ia. This apparent loss of the capacity for Ia expression, and presumably antigen presentation, in oligodendrocytes (the cells which produce myelin in the CNS) is of particular interest in view of the ability of immunization of myelin components to produce autoimmune\u2010mediated paralytic disease.<\/jats:p>","DOI":"10.1002\/eji.1830180808","type":"journal-article","created":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T07:20:02Z","timestamp":1172733602000},"page":"1195-1201","source":"Crossref","is-referenced-by-count":30,"title":["The differentiation of O\u20102A progenitor cells into oligodendrocytes is associated with a loss of inducibility of Ia antigens"],"prefix":"10.1002","volume":"18","author":[{"given":"Virginia L.","family":"Calder","sequence":"first","affiliation":[]},{"given":"Guus","family":"Wolswijk","sequence":"additional","affiliation":[]},{"given":"Mark","family":"Noble","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2005,11,22]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"197","volume":"30","author":"McDevitt H. 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