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Based on the characterization of the released human L chain as a molecule 10 kDa smaller than the cell surface receptor, either proteolytic cleavage or differential splicing of the L chain\u2010encoding mRNA have been suggested as mechanisms underlying the receptor release. Combining affinity labeling of the L chain with <jats:sup>l25<\/jats:sup>I\u2010labeled IL 2 and immunoprecipitation with L chain\u2010specific monoclonal antibodies applied for the detection of soluble mouse IL 2R revealed the existence of two classes of soluble receptors, one being of the same size as cell surface expressed L chain, the other of 45\u2010kDa apparnent molecular mass. These findings raise the possibility of mechanisms of receptor release other than those discussed for human L chain.<\/jats:p>","DOI":"10.1002\/eji.1830181133","type":"journal-article","created":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T01:04:54Z","timestamp":1172711094000},"page":"1855-1858","source":"Crossref","is-referenced-by-count":27,"title":["Demonstration of two distinct forms of released low\u2010affinity type interleukin 2 receptors"],"prefix":"10.1002","volume":"18","author":[{"given":"Olivera","family":"Josimovic\u2010Alasevic","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Herrmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tibor","family":"Diamantstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,22]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830180713"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.167.3.1265"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.83.24.9694"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.165.1.223"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.84.7.2002"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/327518a0"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0171-2985(87)80024-4"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.139.6.1918"},{"key":"e_1_2_1_10_2","doi-asserted-by":"crossref","first-page":"3841","DOI":"10.4049\/jimmunol.137.12.3841","volume":"137","author":"Rubin L. 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