{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T14:57:14Z","timestamp":1761058634671},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,12,6]],"date-time":"2005-12-06T00:00:00Z","timestamp":1133827200000},"content-version":"vor","delay-in-days":6152,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[1989,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>MLR3 molecule is a membrane glycoprotein (mol. mass range 28\u201334 kDa) present on activated, but not resting human peripheral T cells, B cells and thymocytes. Its kinetics of appearance on the cell surface (3 h after the addition of the inductive signal to the cells) suggests that it is an early activation antigen. The proliferative response of cultured T and B lymphocytes and thymocytes to different activation signals is inhibited by the addition of MLR3 monoclonal antibody. Moreover the antibody in combination with non\u2010mitogenic doses of phorbol myristate acetate leads to proliferation of thymocytes and resting B and T lymphocytes. In the latter, synthesis of interleukin 2 is also induced. Biochemical analysis of MLR3 antigen indicates that it is a phosphorylated protein with N\u2010linked sugar moieties. Together these data suggest a role for MLR3 antigen in the signal transduction process during activation, both for mature lymphocytes and for T cell precursors.<\/jats:p>","DOI":"10.1002\/eji.1830190216","type":"journal-article","created":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T10:41:59Z","timestamp":1172745719000},"page":"323-328","source":"Crossref","is-referenced-by-count":49,"title":["MLR3 molecule is an activation antigen shared by human B, T lymphocytes and T cell precursors"],"prefix":"10.1002","volume":"19","author":[{"given":"Angela","family":"Risso","sequence":"first","affiliation":[]},{"given":"Maria Elisabetta","family":"Cosulich","sequence":"additional","affiliation":[]},{"given":"Anna","family":"Rubartelli","sequence":"additional","affiliation":[]},{"given":"Maria Rosaria","family":"Mazza","sequence":"additional","affiliation":[]},{"given":"Antonio","family":"Bargellesi","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2005,12,6]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.1983.tb01085.x"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.iy.04.040186.003113"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.161.6.1450"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(84)90039-4"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.162.3.823"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.161.6.1513"},{"key":"e_1_2_1_8_2","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.4049\/jimmunol.138.5.1346","volume":"138","author":"Fleischer B.","year":"1987","journal-title":"J. Immunol."},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0008-8749(87)90133-X"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.122.2.423"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.82.6.1766"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(87)90018-1"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.84.23.8598"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.84.12.4205"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-1759(77)90065-5"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0008-8749(87)90223-1"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/227680a0"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.83.8.2614"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.94.2.325"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(82)90278-1"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830101006"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830180303"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/331393a0"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.124.6.2708"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.166.2.619"},{"key":"e_1_2_1_26_2","unstructured":"Delia D. Traversari C. Ballinari D. Cattoretti G. Fontanella E. Polli N.andDelia Porta G. Immunology1988 in press."}],"container-title":["European Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Feji.1830190216","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/eji.1830190216","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T23:17:06Z","timestamp":1697930226000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/eji.1830190216"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,2]]},"references-count":25,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1989,2]]}},"alternative-id":["10.1002\/eji.1830190216"],"URL":"https:\/\/doi.org\/10.1002\/eji.1830190216","archive":["Portico"],"relation":{},"ISSN":["0014-2980","1521-4141"],"issn-type":[{"value":"0014-2980","type":"print"},{"value":"1521-4141","type":"electronic"}],"subject":[],"published":{"date-parts":[[1989,2]]}}}