{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T21:23:53Z","timestamp":1772832233918,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2005,12,1]],"date-time":"2005-12-01T00:00:00Z","timestamp":1133395200000},"content-version":"vor","delay-in-days":5966,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[1989,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The vast majority of T cells in man and mouse use the \u03b1\/\u03b2 form of T cell receptor (TcR), and express either CD4 or CD8, whereas the small subset of \u03b3\/\u03b4 T cells are usually CD4<jats:sup>\u2010<\/jats:sup>CD8<jats:sup>\u2010<\/jats:sup>. In contrast to man and mouse, the \u03b3\/\u03b4 subset in sheep, defined here using an anti\u2010\u03b3\/\u03b4 monoclonal antibody (mAb), comprises 30%\u201360% of T cells. We show that \u03b3\/\u03b4 T cells in sheep express a unique surface molecule termed T19 which is 215 kDa in size and unrelated to either CD45 or the TcR. The T19 molecule was expressed at a distinct stage during \u03b3\/\u03b4 T cell ontogeny within the thymus, since \u03b3\/\u03b4 thymocytes which appeared early in fetal ontogeny were T19<jats:sup>\u2010<\/jats:sup> and also major histocompatibility complex (MHC) class I<jats:sup>\u2010<\/jats:sup> and localized almost exclusively to the outer cortex and cortex of the thymus. \u201cMature\u2010type\u201d \u03b3\/\u03b4 thymocytes which emerged late in thymic development were T19<jats:sup>+<\/jats:sup> and MHC class I<jats:sup>+<\/jats:sup> and localized predominantly to the thymic medulla. The sequence of events indicated that these cells were most likely derived from the early \u03b3\/\u03b4 thymocytes. These medullary \u03b3\/\u03b4 thymocytes showed a very distinctive association with Hassall's corpuscles, suggesting a role for these structures in \u03b3\/\u03b4 thymocyte maturation.<\/jats:p><jats:p>In the periphery, T19 was expressed exclusively within the \u03b3\/\u03b4 T cell subset, however some \u03b3\/\u03b4 T cells were T19<jats:sup>\u2010<\/jats:sup>. In particular, a large proportion of \u03b3\/\u03b4 T cells within intestinal epithelium lacked T19, indicating a correlation between T19 expression and either function or homing patterns of \u03b3\/\u03b4 T cells. Both T19<jats:sup>+<\/jats:sup> and T19<jats:sup>\u2010<\/jats:sup> \u03b3\/\u03b4 T cells were CD2<jats:sup>\u2010<\/jats:sup>, and expressed low levels of LFA\u20101 and CD5. In addition, \u03b3\/\u03b4 T cells recirculated differently from other T cells, and appeared not to enter mesenteric lymph nodes at all from the blood. We propose that T19 is a maturation marker for \u03b3\/\u03b4 T cells. In addition, the exclusive expression of T19 by \u03b3\/\u03b4 T cells indicates that this molecule most likely serves a fundamental role in the interactions and function of \u03b3\/\u03b4 T cells.<\/jats:p>","DOI":"10.1002\/eji.1830190820","type":"journal-article","created":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T11:16:23Z","timestamp":1172747783000},"page":"1477-1483","source":"Crossref","is-referenced-by-count":164,"title":["\u03b3\/\u03b4 T cells express a unique surface molecule appearing late during thymic development"],"prefix":"10.1002","volume":"19","author":[{"given":"Charles R.","family":"Mackay","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie\u2010Fran\u00e7oise","family":"Beya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Polly","family":"Matzinger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.iy.05.040187.002443"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/322145a0"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.3787252"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/323638a0"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(88)91267-4"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/333855a0"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/336479a0"},{"key":"e_1_2_1_9_2","doi-asserted-by":"crossref","first-page":"2200","DOI":"10.4049\/jimmunol.141.7.2200","volume":"141","author":"Bucy R. 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