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Nevertheless, two sets of anti\u2010CD23 mAb could be distinguished. The first set, including mAb25, was able to decrease significantly hIL 4\u2010induced IgE synthesis by mononuclear cells. The second set, including EBVCS#1, did not affect hIL 4\u2010induced IgE synthesis. All the anti\u2010CD23 mAb were able to bind specifically to a human B cell line expressing recombinant CD23. Inhibition experiments revealed that the two sets of anti\u2010CD23 mAb did not recognize the same epitope on the CD23 antigen. In fact, all the anti\u2010CD23 mAb, except EBVCS#1, were able to inhibit IgE binding to CD23 on RPMI 8866 cells. Moreover, the first set of antibodies, which decreased IgE production, was able to up\u2010regulate membrane CD23 expression on hIL4\u2010stimulated tonsillar mononuclear cells. Conversely, EBVCS#1, which had no effect on IgE production, did not affect hIL 4\u2010induced CD23 expression. These results indicate that CD23 plays a key role in human IgE synthesis.<\/jats:p>","DOI":"10.1002\/eji.1830200120","type":"journal-article","created":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T11:06:55Z","timestamp":1172747215000},"page":"139-144","source":"Crossref","is-referenced-by-count":56,"title":["Inhibition of human interleukin 4\u2010induced IgE synthesis by a subset of anti\u2010CD23\/Fc\u03f5RII monoclonal antibodies"],"prefix":"10.1002","volume":"20","author":[{"given":"Jean\u2010Yves","family":"Bonnefoy","sequence":"first","affiliation":[]},{"given":"John","family":"Shields","sequence":"additional","affiliation":[]},{"given":"Jean\u2010Jacques","family":"Mermod","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2005,11,17]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"crossref","first-page":"1838","DOI":"10.4049\/jimmunol.117.5_Part_2.1838","volume":"117","author":"Gonzalez\u2010Molina A.","year":"1976","journal-title":"J. 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