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We have attempted to localize the sequences in the constant region which are responsible for this difference by examining the intravascular metabolism of mutant immunoglobulins that were generated in tissue culture and have undergone deletions of individual constant region domains or contain different combinations of \u03b3<jats:sub>2b<\/jats:sub> and \u03b3<jats:sub>2a<\/jats:sub> C<jats:sub>H<\/jats:sub>2 and C<jats:sub>H<\/jats:sub>3 domains. Our results suggest that the regulation of intravascular metabolism is complex but indicate that sequences in the C<jats:sub>H<\/jats:sub>3 domain are important in determining the different intravascular half\u2010lives of IgG<jats:sub>2b<\/jats:sub> and IgG<jats:sub>2a<\/jats:sub> antibodies in the mouse.<\/jats:p>","DOI":"10.1002\/eji.1830200921","type":"journal-article","created":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T03:25:28Z","timestamp":1172719528000},"page":"2021-2027","source":"Crossref","is-referenced-by-count":25,"title":["Intravascular metabolism of normal and mutant mouse immunoglobulin molecules"],"prefix":"10.1002","volume":"20","author":[{"given":"Roberta R.","family":"Pollock","sequence":"first","affiliation":[]},{"given":"Deborah L.","family":"French","sequence":"additional","affiliation":[]},{"given":"Joshua P.","family":"Metlay","sequence":"additional","affiliation":[]},{"given":"Barbara K.","family":"Birshtein","sequence":"additional","affiliation":[]},{"given":"Matthew D.","family":"Scharff","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2005,11,17]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"1","volume":"13","author":"Waldmann T. 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