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We have studied the effect of CD45 cross\u2010linking on the early signals induced by CD3 in mouse T cells. We show that CD45 cross\u2010linking inhibits the increase in inositol phosphates and cytoplasmic Ca<jats:sup>2+<\/jats:sup> induced by cross\u2010linking of CD3. This indicates that CD45 is involved in the regulation of phospholipase C.<\/jats:p>","DOI":"10.1002\/eji.1830210129","type":"journal-article","created":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T04:42:00Z","timestamp":1172724120000},"page":"195-201","source":"Crossref","is-referenced-by-count":13,"title":["Evidence that the CD45 phosphatase regulates the activity of the phospholipase C in mouse T lymphocytes"],"prefix":"10.1002","volume":"21","author":[{"given":"Jacqueline","family":"Marvel","sequence":"first","affiliation":[]},{"given":"Galia","family":"Rimon","sequence":"additional","affiliation":[]},{"given":"Peter","family":"Tatham","sequence":"additional","affiliation":[]},{"given":"Shamshad","family":"Cockcroft","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2005,11,17]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.iy.07.040189.002011"},{"key":"e_1_2_1_3_2","doi-asserted-by":"crossref","first-page":"315","DOI":"10.4049\/jimmunol.143.1.315","volume":"143","author":"Chang H. 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