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In contrast, CD2 function is essentially optimal in non\u2010activated T cells and undergoes no detectable modification within 12 h of TcR stimulation. Protein kinase C activation augments LFA\u20101 but not CD2 adhesion function and cyclic AMP reduces LFA\u20101 adhesion without affecting CD2\u2010LFA\u20103 interactions. Up\u2010regulation of the LFA\u20101 pathway occurs in the absence of any detectable surface redistribution of this molecule, suggesting an activation dependent modification leading to a high\u2010affinity ICAM\u20101 binding state. The TcR independence of CD2 adhesion function implies a critical role of the CD2 pathway in initiating cell\u2010cell interactions prior to TcR engagement and LFA\u20101\u2010ICAM\u20101 binding and underscores the complementary nature of the CD2 and LFA\u20101 adhesion pathways during the immune response.<\/jats:p>","DOI":"10.1002\/eji.1830210311","type":"journal-article","created":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T12:39:06Z","timestamp":1172752746000},"page":"605-610","source":"Crossref","is-referenced-by-count":50,"title":["Complementary roles for CD2 and LFA\u20101 adhesion pathways during T cell activation"],"prefix":"10.1002","volume":"21","author":[{"given":"Philippe E.","family":"Moingeon","sequence":"first","affiliation":[]},{"given":"Jeanne L.","family":"Lucich","sequence":"additional","affiliation":[]},{"given":"Christopher C.","family":"Stebbins","sequence":"additional","affiliation":[]},{"given":"Michael A.","family":"Recny","sequence":"additional","affiliation":[]},{"given":"Barbara P.","family":"Wallner","sequence":"additional","affiliation":[]},{"given":"Shigeo","family":"Koyasu","sequence":"additional","affiliation":[]},{"given":"Ellis L.","family":"Reinherz","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2005,11,22]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.168.3.1145"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/339312a0"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.87.7.2603"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/331086a0"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/339061a0"},{"key":"e_1_2_1_7_2","doi-asserted-by":"crossref","first-page":"2180","DOI":"10.4049\/jimmunol.132.5.2180","volume":"132","author":"Krensky A. 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