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The combinatorial process of gene recombination should allow the generation of eight distinct immunoglobulin light chains. We have therefore investigated the probability of obtaining such chains among the mature \u03bb B cell repertoire. We analyze serum \u03bb immunoglobulins and \u03bb B cell clones induced by treatment with rabbit anti\u2010\u0394 antibodies coupled to LPS. Confirming previous data obtained by others, our results indicate that the rearrangements of \u0394 segments take place within each V<jats:sub>\u03bb<\/jats:sub>\u2010J<jats:sub>\u03bb<\/jats:sub>\u2010C<jats:sub>\u03bb<\/jats:sub> cluster, thereby defining a unit of recombination. Our results also provide no evidence for the use of undescribed segments as has been recently suggested by the finding of the V<jats:sub>\u03bb<\/jats:sub>x segment.<\/jats:p>","DOI":"10.1002\/eji.1830210408","type":"journal-article","created":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T12:38:41Z","timestamp":1172752721000},"page":"907-911","source":"Crossref","is-referenced-by-count":36,"title":["V<sub>\u03bb<\/sub>\u2010J<sub>\u03bb<\/sub> rearrangements are restricted within a V\u2010J\u2010C recombination unit in the mouse"],"prefix":"10.1002","volume":"21","author":[{"given":"Pierre","family":"Sanchez","sequence":"first","affiliation":[]},{"given":"Bertrand","family":"Nadel","sequence":"additional","affiliation":[]},{"given":"Pierre\u2010Andr\u00e9","family":"Cazenave","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2005,11,22]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-2776(08)60650-1"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.75.3.1485"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(78)90041-7"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.79.2.530"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/295428a0"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.166.1.265"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830170525"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.9.2.711"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00373642"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.84.24.9185"},{"key":"e_1_2_1_12_2","doi-asserted-by":"crossref","first-page":"2816","DOI":"10.4049\/jimmunol.144.7.2816","volume":"144","author":"Sanchez P.","year":"1990","journal-title":"J. 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