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The peptide with the highest affinity corresponds to the sequence of nine amino acids (NP366\u2013374) recently isolated from cells infected with influenza. This peptide forms stable complexes with half\u2010lives &gt; 110 h at 4 \u00b0C, 39 h at 22 \u00b0C and 3 h at 37 \u00b0C. Small increases in length of the peptide greatly reduce the stability of the complex (t1\/2 \u223c1\u201310 h at 4 \u00b0C). These results may explain the homogeneous length of peptides isolated from class I molecules formed <jats:italic>in vivo<\/jats:italic>, and suggest that class I and II may differ in their dependence on the length of peptides for the formation of stable complexes.<\/jats:p>","DOI":"10.1002\/eji.1830210915","type":"journal-article","created":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T13:01:49Z","timestamp":1172754109000},"page":"2069-2075","source":"Crossref","is-referenced-by-count":139,"title":["The binding affinity and dissociation rates of peptides for class I major histocompatibility complex molecules"],"prefix":"10.1002","volume":"21","author":[{"given":"Vincenzo","family":"Cerundolo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy","family":"Elliott","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Elvin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judy","family":"Bastin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans\u2010Georg","family":"Rammensee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alain","family":"Townsend","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,22]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(85)90103-5"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(86)90019-X"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/324578a0"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00346521"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.166.3.678"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/326881a0"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(88)91043-4"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.168.2.559"},{"key":"e_1_2_1_10_2","doi-asserted-by":"crossref","first-page":"3965","DOI":"10.1128\/jvi.62.11.3965-3972.1988","volume":"62","author":"Del Val M.","year":"1988","journal-title":"J. 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