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Here we report on an HLA\u2010DR7\u2010restricted human CD4 T cell clone (TC9), which was isolated from a healthy donor and recognizes human CII. After screening CNBr fragments of CII and tryptic fragments derived thereof, the T cell epitope could be mapped to amino acid residues 271\u2010285 of the triple helical region of CII that are located within CNBr fragment 11 [\u03b11 (II) CB11]. This epitope was confirmed by a synthetic peptide stimulatory for TC9. The T cell receptor \u03b2 chain of TC9 was cloned using the polymerase chain reaction; it comprises V<jats:sub>\u03b2<\/jats:sub>6.7 and contains besides J<jats:sub>\u03b2<\/jats:sub>2.3 and C<jats:sub>\u03b2<\/jats:sub>2 an as yet undescribed sequence for the D segment.<\/jats:p>","DOI":"10.1002\/eji.1830220109","type":"journal-article","created":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T13:01:26Z","timestamp":1172754086000},"page":"51-56","source":"Crossref","is-referenced-by-count":31,"title":["Specificity and T cell receptor \u03b2 chain usage of a human collagen type II\u2010reactive T cell clone derived from a healthy individual"],"prefix":"10.1002","volume":"22","author":[{"given":"Tan","family":"Yan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harald","family":"Burkhardt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Ritter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Br\u00f6ker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karl Heinz","family":"Mann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolf M.","family":"Bertling","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaus Von Der","family":"Mark","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"Emmrich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,23]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/283666a0"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI108929"},{"key":"e_1_2_1_4_2","first-page":"524","volume":"57","author":"Rubin A. 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