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If titered out to 2 \u00d7 10\u221210<\/jats:sup> \u2013 4 \u00d7 10\u221210<\/jats:sup>M in CTL\u2010mediated lysis assays and to 3 \u00d7 10\u22129<\/jats:sup>M in an HLA\u2010A2 assembly\u2010stabilization assay in cell lysates. The peptide was shown to make probable contacts with its carboxy terminus close to residue 116 in the floor of the cleft of HLA\u2010A2, close to the F pocket. The side chain of the amino\u2010terminal amino acid was unimportant, but its free amino and carbonyl groups in the A pocket appeared important in optimizing peptide presentation. The B pocket probably accommodates the side chain of residue 2 (isoleucine) and was shown to be critical in peptide presentation.<\/jats:p>","DOI":"10.1002\/eji.1830220404","type":"journal-article","created":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T14:35:32Z","timestamp":1172759732000},"page":"903-907","source":"Crossref","is-referenced-by-count":89,"title":["Identification of the nonamer peptide from influenza A matrix protein and the role of pockets of HLA\u2010A2 in its recognition by cytotoxic T lymphocytes"],"prefix":"10.1002","volume":"22","author":[{"given":"Joanne","family":"Morrison","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Elvin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"France","family":"Latron","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frances","family":"Gotch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Moots","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jack L.","family":"Strominger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"McMichael","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,17]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.165.2.408"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/326881a0"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.168.6.2045"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.85.23.9194"},{"key":"e_1_2_1_6_2","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.4049\/jimmunol.146.4.1226","volume":"146","author":"Engelhard V. 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