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However, following T cell activation with phorbol esters and ionomycin, the chimeric protein bound specifically to activated human T cells and precipitated a 35\u2010kDa protein from such cells. The induction of the CD40 ligand was detectable on the cell surface after 1 h, with maximal expression after 8 h of stimulation. The T cells expressing CD40 ligand were predominantly CD4 positive, although a proportion of CD8\u2010positive cells also expressed the protein. There was no particular correlation with CD45 phenotype. Finally, we found that soluble CD40 inhibited T\u2010dependent B cell proliferation. The results are discussed in the context of cognate interactions between B and T cells.<\/jats:p>","DOI":"10.1002\/eji.1830221016","type":"journal-article","created":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T13:13:36Z","timestamp":1172754816000},"page":"2573-2578","source":"Crossref","is-referenced-by-count":219,"title":["Activated human T cells express a ligand for the human B cell\u2010associated antigen CD40 which participates in T cell\u2010dependent activation of B lymphocytes"],"prefix":"10.1002","volume":"22","author":[{"given":"Peter","family":"Lane","sequence":"first","affiliation":[]},{"given":"Andr\u00e9","family":"Traunecker","sequence":"additional","affiliation":[]},{"given":"Sabine","family":"Hubele","sequence":"additional","affiliation":[]},{"given":"Seiji","family":"Inui","sequence":"additional","affiliation":[]},{"given":"Antonio","family":"Lanzavecchia","sequence":"additional","affiliation":[]},{"given":"David","family":"Gray","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2005,11,17]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/356397a0"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.83.12.4494"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/342929a0"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1702555"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1989.tb03521.x"},{"key":"e_1_2_1_7_2","doi-asserted-by":"crossref","first-page":"620","DOI":"10.4049\/jimmunol.148.2.620","volume":"148","author":"Torres R. 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