{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T22:11:56Z","timestamp":1780351916302,"version":"3.54.1"},"reference-count":25,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2005,11,17]],"date-time":"2005-11-17T00:00:00Z","timestamp":1132185600000},"content-version":"vor","delay-in-days":4795,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[1992,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The effect of alanine substitution on the major histocompatibility complex (MHC) binding and T cell receptor recognition of the K<jats:sup>b<\/jats:sup>\u2010restricted ovalbumin 257\u2013264 peptide was investigated. Positions 3, 5 and 8 of the octamer were important for K<jats:sup>b<\/jats:sup> binding, as predicted from the motifs found in K<jats:sup>b<\/jats:sup>\u2010associated peptides, while mutations at positions 4, 6 and 7 affected cytotoxic T lymphocyte recognition. Substitutions at positions 1 and 2 had very minor effects on T cell recognition. In addition, we tested the capacity of sequence motifs to predict MHC binding by analysis of a series of peptides which all bear the minimal K<jats:sup>b<\/jats:sup> motif. We found that possession of good motifs was not always sufficient to give strong MHC binding, indicating secondary effects of the residues flanking the \u201eMHC anchor\u201d\ufe01 positions.<\/jats:p>","DOI":"10.1002\/eji.1830221028","type":"journal-article","created":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T13:13:36Z","timestamp":1172754816000},"page":"2663-2667","source":"Crossref","is-referenced-by-count":88,"title":["Dissection of major histocompatibility complex (MHC) and T cell receptor contact residues in a K<sup>b<\/sup>\u2010restricted ovalbumin peptide and an assessment of the predictive power of MHC\u2010binding motifs"],"prefix":"10.1002","volume":"22","author":[{"given":"Stephen C.","family":"Jameson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Bevan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,11,17]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(86)90019-X"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.iy.07.040189.003125"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/351290a0"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.24.11032"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/353326a0"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/353852a0"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830211136"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/353321a0"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/353355a0"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/348248a0"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830201111"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(88)91043-4"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.162.6.1745"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/319675a0"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.79.15.4737"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/340443a0"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/346476a0"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(90)90020-F"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.7.3135"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830210909"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(90)90716-R"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/348213a0"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(91)90018-O"},{"key":"e_1_2_1_25_2","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.4049\/jimmunol.148.6.1871","volume":"148","author":"Romero P.","year":"1992","journal-title":"J. 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