{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T10:14:21Z","timestamp":1770718461076,"version":"3.49.0"},"reference-count":27,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2005,11,23]],"date-time":"2005-11-23T00:00:00Z","timestamp":1132704000000},"content-version":"vor","delay-in-days":4770,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[1992,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The T cell surface molecule CD2 forms, with its counter\u2010receptor CD58 (LFA\u20103), a powerful adhesion\/activation pathway. There is some evidence that CD2 might bind more than a single ligand. Chinese hamster ovary cells (CHO) expressing human CD59 after cDNA transfection (CD59<jats:sup>+<\/jats:sup>CHO) form rosettes with human T cells; these rosettes are inhibited in a dose\u2010dependent fashion by the CD59 monoclonal antibody (mAb) H19 and by the CD2 mAb O275 known to block natural rosettes, but not by the CD2R mAb D66, a poor rosette blocker. CD2<jats:sup>+<\/jats:sup>CHO transfectants form rosettes with human erythrocytes; these rosettes are inhibited by the CD59 mAb H19 in addition to CD2 mAb O275 and CD58 mAb; murine thymoma cells expressing human CD2 form rosettes with CD59<jats:sup>+<\/jats:sup>CHO cells that again are blocked by CD59 H19 and by CD2 O275 mAb. In a marked contrast with H19, two others CD59 mAb, YTH 53.1 and MEM 43, which react with a different epitope on CD59, led to a 50% \u221270% increase of the number of cells forming rosettes. In addition to rosette experiments, the binding of <jats:sup>125<\/jats:sup>I\u2010labeled CD59 molecules to CD2<jats:sup>+<\/jats:sup>CHO cells was specifically inhibited by unlabeled CD59 molecule and CD2 mAb. Furthermore, the binding of CD59 molecules to resting T cells induced expression of CD2R epitopes. These results directly show that CD2 binds CD59 and that subtle molecular changes occur upon binding.<\/jats:p>","DOI":"10.1002\/eji.1830221128","type":"journal-article","created":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T13:11:40Z","timestamp":1172754700000},"page":"2943-2947","source":"Crossref","is-referenced-by-count":66,"title":["CD59 molecule: A second ligand for CD2 in T cell adhesion"],"prefix":"10.1002","volume":"22","author":[{"given":"Marcel","family":"Deckert","sequence":"first","affiliation":[]},{"given":"Joanna","family":"Kubar","sequence":"additional","affiliation":[]},{"given":"Didier","family":"Zoccola","sequence":"additional","affiliation":[]},{"given":"Ghislaine","family":"Bernard\u2010Pomier","sequence":"additional","affiliation":[]},{"given":"Pavla","family":"Angelisova","sequence":"additional","affiliation":[]},{"given":"Vaclav","family":"Horejsi","sequence":"additional","affiliation":[]},{"given":"Alain","family":"Bernard","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2005,11,23]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(84)90039-4"},{"key":"e_1_2_1_3_2","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.4049\/jimmunol.135.3.1624","volume":"135","author":"Brottier P.","year":"1985","journal-title":"J. Immunol."},{"key":"e_1_2_1_4_2","first-page":"272","volume-title":"Leucocyte Typing IV","author":"Valentin H.","year":"1989"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.163.3.654"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/326298a0"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.137.4.1097"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/326400a0"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.153.1.207"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.155.5.1317"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.165.3.664"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.169.2.503"},{"key":"e_1_2_1_13_2","doi-asserted-by":"crossref","first-page":"3358","DOI":"10.4049\/jimmunol.140.10.3358","volume":"140","author":"Bierer B. E.","year":"1988","journal-title":"J. Immunol."},{"key":"e_1_2_1_14_2","first-page":"123","volume-title":"Leucocyte Typing III","author":"Huet S.","year":"1987"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(89)90039-X"},{"key":"e_1_2_1_16_2","doi-asserted-by":"crossref","first-page":"3498","DOI":"10.4049\/jimmunol.141.10.3498","volume":"141","author":"Parish C. R.","year":"1988","journal-title":"J. Immunol."},{"key":"e_1_2_1_17_2","doi-asserted-by":"crossref","first-page":"3013","DOI":"10.4049\/jimmunol.142.9.3013","volume":"142","author":"Groux H.","year":"1989","journal-title":"J. Immunol."},{"key":"e_1_2_1_18_2","doi-asserted-by":"crossref","first-page":"672","DOI":"10.4049\/jimmunol.148.3.672","volume":"148","author":"Deckert M.","year":"1992","journal-title":"J. Immunol."},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(92)90208-T"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.170.3.637"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/0161-5890(89)90097-7"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(87)90104-8"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/339061a0"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.87.13.5031"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.174.3.561"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI114172"},{"key":"e_1_2_1_27_2","doi-asserted-by":"crossref","first-page":"4092","DOI":"10.4049\/jimmunol.146.12.4092","volume":"146","author":"Korty P. E.","year":"1991","journal-title":"J. Immunol."},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-199204000-00004"}],"container-title":["European Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Feji.1830221128","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/eji.1830221128","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T16:55:35Z","timestamp":1698080135000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/eji.1830221128"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,11]]},"references-count":27,"journal-issue":{"issue":"11","published-print":{"date-parts":[[1992,11]]}},"alternative-id":["10.1002\/eji.1830221128"],"URL":"https:\/\/doi.org\/10.1002\/eji.1830221128","archive":["Portico"],"relation":{},"ISSN":["0014-2980","1521-4141"],"issn-type":[{"value":"0014-2980","type":"print"},{"value":"1521-4141","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,11]]}}}