{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T17:43:42Z","timestamp":1761155022084},"reference-count":20,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2005,11,23]],"date-time":"2005-11-23T00:00:00Z","timestamp":1132704000000},"content-version":"vor","delay-in-days":4770,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[1992,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Tumor necrosis factor\u2010\u03b1 (TNF\u2010\u03b1), a mononuclear phagocyte\u2010derived peptide is known to participate in the pathogenesis of fever. To determine whether a feedback mechanism exists by which elevated temperatures influence TNF\u2010\u03b1 generation, we have examined the effects of heat shock on the <jats:italic>in vitro<\/jats:italic> synthesis of TNF\u2010\u03b1 by rat glomeruli, inflammatory peritoneal macrophages and blood monocytes. Preexposure of peritoneal macrophages to elevated temperatures for 20 min decreased the subsequent lipopolysaccharide\u2010induced release of TNF\u2010\u03b1 bioactivity. The mean reductions were 11.9 \u00b1 86.3 \u00b1 12.0, and 95.2 \u00b1 3.5% after pretreatment at 39, 41 and 43\u00b0C, respectively. Reductions, that were transient, were maximum when lipopolysaccharide was added 0\u20132 h after heat shock. They correlated with the decreased release of immunoreactive TNF\u2010\u03b1 and the decreased expression of both cell\u2010associated TNF\u2010\u03b1 molecule and TNF\u2010\u03b1 mRNA. Heat shock\u2010induced inhibition of TNF\u2010\u03b1 release was independent of variations of prostaglandin synthesis, but was possibly related to the induction of heat\u2010shock proteins since (a) macrophages exposed to heat shock synthesized the major 70\u2010 and 90\u2010kDa heat\u2010shock proteins, and (b) chemical inducers of the heat\u2010shock response were also effective inhibitors of TNF\u2010\u03b1 release. The mean reduction of TNF\u2010\u03b1 release after pretreatment at 41\u00b0C was found to be identical in glomerular tissue (82.0 \u00b1 7.5%), but significantly less in blood monocytes (43.9 \u00b1 10.9%). This supports the hypothesis that a negative\u2010feedback mechanism exists between elevated temperature and lipopolysaccharide\u2010induced TNF\u2010\u03b1 synthesis, and suggests that this regulation is less active in blood monocytes than in tissue macrophages.<\/jats:p>","DOI":"10.1002\/eji.1830221133","type":"journal-article","created":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T13:11:40Z","timestamp":1172754700000},"page":"2983-2987","source":"Crossref","is-referenced-by-count":38,"title":["Heat shock prevents lipopolysaccharide\u2010induced tumor necrosis factor\u2010\u03b1 synthesis by rat mononuclear phagocytes"],"prefix":"10.1002","volume":"22","author":[{"given":"Bruno","family":"Fouqueray","sequence":"first","affiliation":[]},{"given":"Carole","family":"Philippe","sequence":"additional","affiliation":[]},{"given":"Abdelaziz","family":"Amrani","sequence":"additional","affiliation":[]},{"given":"Jo\u00eblle","family":"Perez","sequence":"additional","affiliation":[]},{"given":"Laurent","family":"Baud","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2005,11,23]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0090-1229(90)90094-7"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)60727-6"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(86)91224-6"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198806093182301"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0090-1229(87)90087-0"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI115184"},{"key":"e_1_2_1_8_2","first-page":"304","volume":"73","author":"Kappel M.","year":"1991","journal-title":"Immunology"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.1990.tb03338.x"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI111714"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.141.2.512"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1991.103"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1990.16"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1989.98"},{"key":"e_1_2_1_15_2","doi-asserted-by":"crossref","first-page":"2027","DOI":"10.4049\/jimmunol.141.6.2027","volume":"141","author":"Schmidt J. 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