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Of these APC types, only dendritic cells (DC) and RMA\u2010S lymphoma cells could induce primary CTL responses, but by divergent mechanisms. DC were capable of generating primary virus\u2010specific CTL, either by presenting viral peptide or processed infectious virus. In contrast, RMA\u2010S cells could not present endogenous antigen, <jats:italic>e. g.<\/jats:italic> after virus infection, but this cell line very efficiently presented exogenous viral peptides to induce primary virus\u2010specific CTL <jats:italic>in vitro.<\/jats:italic> Spleen cells, lipopolysaccharide\u2010induced B cell blasts or the non\u2010mutated RMA cells did not have the ability to trigger unprimed T cells by single <jats:italic>in vitro<\/jats:italic> stimulation. We have investigated several characteristics important for primary CTL response induction by DC and RMA\u2010S cells (summarized in Fig. 6). Primary CTL response induction by DC or RMA\u2010S cells was blocked by anti\u2010LFA\u20101 or anti\u2010CD8 monoclonal antibodies (mAb). DC rapidly aggregated with unprimed T cells, which was independent of LFA\u20101 and CD8 molecules. RMA\u2010S cells did not form conjugates with unprimed T cells. Despite their abundant major histocompatibility complex (MHC) class I cell\u2010surface expression, DC did not bind much exogenously added viral peptide. In contrast, the MHC class I molecules on RMA\u2010S cells bound a large quantity of exogenously administered peptide. Powerful adhesion by DC and high expression of relevant MHC\/peptide complexes on RMA\u2010S cells are important features in the initial contact with unprimed T lymphocytes. In a later stage of contact, both DC and RMA\u2010S cells activate LFA\u20101 (and CD8) molecules at the T cell surface to strengthen and maintain the contact between T cell and APC.<\/jats:p>","DOI":"10.1002\/eji.1830221137","type":"journal-article","created":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T13:11:40Z","timestamp":1172754700000},"page":"3013-3020","source":"Crossref","is-referenced-by-count":37,"title":["Mechanisms of induction of primary virus\u2010specific cytotoxic T lymphocyte responses"],"prefix":"10.1002","volume":"22","author":[{"given":"Marloes L. H.","family":"De Bruijn","sequence":"first","affiliation":[]},{"given":"John D.","family":"Nieland","sequence":"additional","affiliation":[]},{"given":"Ton N. M.","family":"Schumacher","sequence":"additional","affiliation":[]},{"given":"Hidde L.","family":"Ploegh","sequence":"additional","affiliation":[]},{"given":"W.","family":"Martin Kast","sequence":"additional","affiliation":[]},{"given":"Cornelis J. 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