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Naive BALB\/c (H\u20102<jats:sup>d<\/jats:sup>) splenocytes did not respond to the stimulation with only NPP with the generation of effector T<jats:sub>c<\/jats:sub> cells specific for influenza A virus\u2010infected target cells <jats:italic>in vitro<\/jats:italic>. However, they were able to do so if cultured with NPP in the presence of IL\u20107. IL\u20107 activity in this system differed significantly from IL\u20102 activity in the specificity of the effect. The use of exogenous IL\u20102, instead of IL\u20107, with NPP resulted in the induction of lytic cells that lysed both influenza virus\u2010infected and uninfected syngeneic target cells. These results suggest that IL\u20107 is a potent regulatory cytokine in the antigen\u2010specific activation of resting naive T<jats:sub>c<\/jats:sub> cell precursors and may provide the necessary conditions for the induction of human primary T<jats:sub>c<\/jats:sub> cells <jats:italic>in vitro<\/jats:italic>.<\/jats:p>","DOI":"10.1002\/eji.1830221224","type":"journal-article","created":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T13:11:23Z","timestamp":1172754683000},"page":"3183-3185","source":"Crossref","is-referenced-by-count":22,"title":["Induction of primary anti\u2010viral cytotoxic T cells by <i>in vitro<\/i> stimulation with short synthetic peptide and interleukin\u20107"],"prefix":"10.1002","volume":"22","author":[{"given":"Ferdynand J.","family":"Kos","sequence":"first","affiliation":[]},{"given":"Arno","family":"M\u00fcllbacher","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2005,11,23]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"985","volume-title":"Fundamental Immunology","author":"Ada G. 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