{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T10:14:26Z","timestamp":1770718466853,"version":"3.49.0"},"reference-count":30,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2005,12,7]],"date-time":"2005-12-07T00:00:00Z","timestamp":1133913600000},"content-version":"vor","delay-in-days":4542,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[1993,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Clonal deletion represents an important mechanism for the establishment of tolerance, by the elimination of autoreactive T cells. Deletion is accomplished by programmed cell death, termed apoptosis, induced by mobilization of the T cell receptor (TCR) on both thymocytes and mature T cells. The mechanism which drives T cells towards cell death or cell proliferation after TCR mobilization remains unclear. We show here that the mobilization of the CD3\/TCR complex of both CD4<jats:sup>+<\/jats:sup> and CD8<jats:sup>+<\/jats:sup> single\u2010positive medullary human thymocytes and human mature activated T cells, in the absence of accessory cells, leads to an activation\u2010induced cell death process by apoptosis. In both cases, apoptosis was associated with interferon (IFN)\u2010\u03b3 gene expression and secretion in the absence of interleukin (IL)\u20102 gene expression; and the addition of anti\u2010IFN\u2010\u03b3 antibody prevented cell death. Apoptosis could also be prevented by cyclosporin A (CsA) treatment and could be re\u2010induced by the addition of IFN\u2010\u03b3 to CsA\u2010treated cells. Addition of IL\u20102 had two different effects, it prevented apoptosis and also allowed proliferation in response to CD3 monoclonal antibody. Addition of IL\u20101, which induces IL\u20102 gene expression and secretion or addition of accessory cells, had the same preventive effect. These results suggest that the uncoupling of IFN\u2010\u03b3 and IL\u20102 gene expression following CD3\/TCR mobilization initiates apoptosis of human T cells at several different stages during development and activation. We propose that co\u2010signals provided by accessory cells allow a coupling of IL\u20102 gene and IFN\u2010\u03b3 gene expression, and that an essential role for IL\u20102 secretion in T cell activation involves the inhibition of a death program induced by IFN\u2010\u03b3 secretion.<\/jats:p>","DOI":"10.1002\/eji.1830230734","type":"journal-article","created":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T19:03:53Z","timestamp":1172775833000},"page":"1623-1629","source":"Crossref","is-referenced-by-count":81,"title":["CD3\u2010mediated apoptosis of human medullary thymocytes and activated peripheral T cells: Respective roles of interleukin\u20101, interleukin\u20102, interferon\u2010\u03b3 and accessory cells"],"prefix":"10.1002","volume":"23","author":[{"given":"Herv\u00e9","family":"Groux","sequence":"first","affiliation":[]},{"given":"Didier","family":"Monte","sequence":"additional","affiliation":[]},{"given":"Benedicte","family":"Plouvier","sequence":"additional","affiliation":[]},{"given":"Andre","family":"Capron","sequence":"additional","affiliation":[]},{"given":"Jean\u2010Claude","family":"Ameisen","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2005,12,7]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830191132"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(87)90568-X"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/337181a0"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.1987.tb00502.x"},{"key":"e_1_2_1_6_2","doi-asserted-by":"crossref","first-page":"16","DOI":"10.4049\/jimmunol.144.1.16","volume":"144","author":"Jenkins M. 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