{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T06:09:51Z","timestamp":1775714991831,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2005,12,7]],"date-time":"2005-12-07T00:00:00Z","timestamp":1133913600000},"content-version":"vor","delay-in-days":4542,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[1993,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>CD69 is a disulfide\u2010linked homo\u2010dimer expressed on the surface of activated T cells, B cells, natural killer cells, neutrophils and platelets. Antibody cross\u2010linking of CD69 in the presence of phorbol ester results in cellular activation events including proliferation and the induction of specific genes. Using an expression cloning strategy we have isolated cDNA encoding human CD69 from a CD4<jats:sup>+<\/jats:sup> T cell clone. Transfection of the cDNA clone in CV\u20101\/EBNA cells results in the expression of a covalently linked homodimer. The cDNA insert hybridizes to a 1.7\u2010kb mRNA in phorbol 12\u2010myristate 13\u2010acetate\u2010 or phytohemoagglutinin\u2010stimulated human T cells. Using the human clone we have isolated cDNA encoding mouse CD69, which, when expressed in human T cells allowed those cells to respond to anti\u2010mouse CD69 antibodies by secreting interleukin\u20102 and interferon\u2010\u03b3. Sequence analysis showed that both mouse and human CD69 are type II membrane glycoproteins related to the NKR\u2010P1 and Ly\u201049 families of natural killer cell activation molecules.<\/jats:p>","DOI":"10.1002\/eji.1830230737","type":"journal-article","created":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T19:03:53Z","timestamp":1172775833000},"page":"1643-1648","source":"Crossref","is-referenced-by-count":109,"title":["Molecular characterization of the early activation antigen CD69: A type II membrane glycoprotein related to a family of natural killer cell activation antigens"],"prefix":"10.1002","volume":"23","author":[{"given":"Steven F.","family":"Ziegler","sequence":"first","affiliation":[]},{"given":"Fred","family":"Ramsdell","sequence":"additional","affiliation":[]},{"given":"Kathryn A.","family":"Hjerrild","sequence":"additional","affiliation":[]},{"given":"Richard J.","family":"Armitage","sequence":"additional","affiliation":[]},{"given":"Kenneth H.","family":"Grabstein","sequence":"additional","affiliation":[]},{"given":"Kathryn B.","family":"Hennen","sequence":"additional","affiliation":[]},{"given":"Terry","family":"Farrah","sequence":"additional","affiliation":[]},{"given":"William C.","family":"Fanslow","sequence":"additional","affiliation":[]},{"given":"Ethan M.","family":"Shevach","sequence":"additional","affiliation":[]},{"given":"Mark R.","family":"Alderson","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2005,12,7]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.164.6.1988"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.84.12.4205"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.168.5.1621"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.169.3.677"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830190216"},{"key":"e_1_2_1_7_2","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.4049\/jimmunol.143.4.1123","volume":"143","author":"Testi R.","year":"1989","journal-title":"J. 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