{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T11:08:02Z","timestamp":1770721682627,"version":"3.49.0"},"reference-count":39,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2005,12,7]],"date-time":"2005-12-07T00:00:00Z","timestamp":1133913600000},"content-version":"vor","delay-in-days":4450,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[1993,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The response of murine intraepithelial lymphocyte (IEL) populations to challenge by <jats:italic>Eimeria vermiformis<\/jats:italic>, a naturally occurring protozoan parasite of the gut epithelium, has been studied. The number of recoverable IEL increased within 3 days post infection, was depleted by day 7 post infection, but was significantly increased again by about day 14 post infection. Special attention was paid to \u03b3 \u03b4<jats:sup>+<\/jats:sup> IEL T cells, because they are of unknown functions. These cells showed changes in numbers similar to the total IEL population. Moreover, by day 3, increased expression was detected among \u03b3 \u03b4 <jats:italic><jats:sup>+<\/jats:sup><\/jats:italic> IEL T cells, of T cell receptor genes not constitutively associated with the intestine. These results demonstrate that the IEL repertoire, and within that, the \u03b3 \u03b4 <jats:italic><jats:sup>+<\/jats:sup><\/jats:italic> T cell repertoire, can be extremely dynamic post infection with a naturally occurring epithelial\u2010tropic pathogen. In considering the potential benefits of such IEL changes, we hypothesize that they may be relevant to the transient protection of the host's epithelium, both from parasitic re\u2010infection, and from potentially damaging inflammation.<\/jats:p>","DOI":"10.1002\/eji.1830231027","type":"journal-article","created":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T18:36:00Z","timestamp":1172774160000},"page":"2557-2564","source":"Crossref","is-referenced-by-count":55,"title":["Dynamic response of murine gut intraepithelial T cells after infection by the coccidian parasite <i>Eimeria<\/i>"],"prefix":"10.1002","volume":"23","author":[{"given":"R.","family":"Craig Findly","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott J.","family":"Roberts","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrian C.","family":"Hayday","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,7]]},"reference":[{"key":"e_1_2_1_2_2","volume-title":"Coccidiosis of Man and Domestic Animals","author":"Long P. 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