{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,28]],"date-time":"2023-10-28T00:18:12Z","timestamp":1698452292028},"reference-count":52,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2005,12,11]],"date-time":"2005-12-11T00:00:00Z","timestamp":1134259200000},"content-version":"vor","delay-in-days":4393,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[1993,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In previous studies, our laboratory demonstrated the utility of the low affinity IgE Fc receptor (Fc\u03f5RII) in delineating a number of murine B cell subsets. In the spleen, the Fc\u03f5RII is expressed on mature conventional B cells but is absent on marginal zone B cells. In the peritoneal cavity, the receptor is present on all conventional B cells, but is not expressed on fresh peritoneal Ly1\/sister B cells. The studies in this report compared the ability of these B cell poputations to isotype switch. Using a lipopolysaccharide (LPS)\u2010 and interleukin (IL)\u20104\u2010driven system, sort\u2010purified Fc\u03f5RII\u2010 positive and \u2010negative B cells from peritoneum and spleen were tested for switching to IgG1, IgE, and IgA. The results demonstrated that regardless of their source, Fc\u03f5RII<jats:sup>+<\/jats:sup> B cells produced significant levels of IgG1 and IgE. Similar results were obtained with Fc\u03f5RII<jats:sup>\u2212<\/jats:sup> (marginal zone) B cells obtained from spleen. In contrast, Fc\u03f5RII<jats:sup>\u2212<\/jats:sup> (Ly1\/sister) peritoneal B cells were found to produce IgG1 and IgA, but were incapable of secreting significant levels of IgE. Further studies tested for LPS and IL\u20104\u2010induced expression of Fc\u03f5RII and Thy1 on the various B cell populations. These experiments demonstrated the induction of the Fc\u03f5RII on all B cells, regardless of their initial resting levels. Additionally, Thy1 was found to be induced only on those B cell subsets capable of producing IgE. Taken together, the results demonstrate a correlation between IgE secretion and Thy1 expression, and no apparent correlation between the presence of the Fc\u03f5RII and isotype commitment.<\/jats:p>","DOI":"10.1002\/eji.1830231225","type":"journal-article","created":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T18:30:22Z","timestamp":1172773822000},"page":"3208-3216","source":"Crossref","is-referenced-by-count":8,"title":["Switching capacity of Fc\u03f5RII\u2010positive and \u2010negative murine B cells"],"prefix":"10.1002","volume":"23","author":[{"given":"Teresa M.","family":"Foy","sequence":"first","affiliation":[]},{"given":"Thomas J.","family":"Waldschmidt","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2005,12,11]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/3.4.305"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1992.tb24599.x"},{"key":"e_1_2_1_4_2","doi-asserted-by":"crossref","first-page":"2290","DOI":"10.4049\/jimmunol.139.7.2290","volume":"139","author":"Conrad D. 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