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It has been thought that the CD4<jats:sup>+<\/jats:sup> lymphocytes are the initiators of the disease, the islet invaders, while CD8<jats:sup>+<\/jats:sup> cells are the effectors, the islet destroyers. We question this interpretation because NOD mice lacking MHC class I molecules, hence CD8<jats:sup>+<\/jats:sup> T cells, do not display even insulitis when expected.<\/jats:p>","DOI":"10.1002\/eji.1830231244","type":"journal-article","created":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T18:30:22Z","timestamp":1172773822000},"page":"3358-3360","source":"Crossref","is-referenced-by-count":142,"title":["Major histocompatibility complex class I molecules are required for the development of insulitis in non\u2010obese diabetic mice"],"prefix":"10.1002","volume":"23","author":[{"given":"Jonathan","family":"Katz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christophe","family":"Benoist","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diane","family":"Mathis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,11]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.iy.08.040190.003243"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1538\/expanim1978.29.1_1"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0952-7915(92)90051-F"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/328432a0"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/345724a0"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/345722a0"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/345727a0"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.176.1.67"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.40.9.1203"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.20.9519"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1763324"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.166.4.823"},{"key":"e_1_2_1_14_2","doi-asserted-by":"crossref","first-page":"52","DOI":"10.4049\/jimmunol.140.1.52","volume":"140","author":"Miller B. 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