{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,27]],"date-time":"2023-10-27T05:10:10Z","timestamp":1698383410573},"reference-count":27,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2005,12,11]],"date-time":"2005-12-11T00:00:00Z","timestamp":1134259200000},"content-version":"vor","delay-in-days":4393,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[1993,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The \u03b2 chain (p75) of the interleukin\u20102 (IL\u20102) receptor (IL\u20102R) is expressed on up to 5\u20107% of fetal thymocytes on day 16 of gestation, declining thereafter to a minute proportion of less than 1% around birth, and of 1\u20102% of adult thymocytes. A significant part of fetal IL\u20102R \u03b2<jats:sup>+<\/jats:sup> thymocytes are \u03b3\u03b4 cells. The precursor\u2010progeny relationships of fetal DL\u20102R\u03b2<jats:sup>+<\/jats:sup> thymocytes to the \u03b1\u03b4 T cell lineage have not been previously studied, nor has their position within the developmental sequence been determined. Here we show that IL\u20102R\u03b2 is expressed on a subset of very immature cells, along with high amounts of Pgp1 and FC\u03b3RII\/III, partially preceding the expression of intracellular CD3\u03f5. IL\u20102\u2010R\u03b2 disappears before expression of IL\u20102R\u03b1. IL\u20102R\u03b2<jats:sup>+<\/jats:sup> cells, purified by sorting on day 15 of gestation, efficiently reconstituted fetal thymic lobes depleted of lymphoid cells by treatment with desoxyguanosine. They developed into T cell receptor (TCR)\u03b1\u03b2<jats:sup>+<\/jats:sup>, TCR\u03b3\u03b4<jats:sup>+<\/jats:sup>, and CD4\/CD8 double\u2010 and single\u2010positive cells in similar proportions as did sorted IL\u20102R\u03b1<jats:sup>+<\/jats:sup> day 15 fetal thymocytes. These data suggest that IL\u20102R\u03b2 expression marks a short period of very early thymocyte development, perhaps immediately after entry into the thymus.<\/jats:p>","DOI":"10.1002\/eji.1830231248","type":"journal-article","created":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T18:30:22Z","timestamp":1172773822000},"page":"3373-3376","source":"Crossref","is-referenced-by-count":9,"title":["Lineage relationships of the fetal thymocyte subset that expresses the \u03b2 chain of the interleukin\u20102 receptor"],"prefix":"10.1002","volume":"23","author":[{"given":"Ingrid","family":"Falk","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christiaan N.","family":"Levelt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaus","family":"Eichmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,11]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0952-7915(92)90003-W"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0952-7915(93)90009-H"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.iy.08.040190.002531"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-2776(08)60643-4"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0952-7915(93)90011-G"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.177.3.707"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(92)90125-V"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.177.4.1079"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/314098a0"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.5.1614"},{"key":"e_1_2_1_12_2","doi-asserted-by":"crossref","first-page":"2222","DOI":"10.4049\/jimmunol.147.7.2222","volume":"147","author":"Tanaka T.","year":"1991","journal-title":"J. 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