{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T03:22:07Z","timestamp":1772248927099,"version":"3.50.1"},"reference-count":12,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,11,23]],"date-time":"2005-11-23T00:00:00Z","timestamp":1132704000000},"content-version":"vor","delay-in-days":4313,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[1994,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We have found a new spontaneous autosomal recessive mutation in mice that causes a systemic absence of lymph nodes and Peyer's patches. The name \u201calymphoplasia\u201d, with the gene symbol <jats:italic>\u201culy\u201d<\/jats:italic>, is proposed for this mutant. The spleen of <jats:italic>alylay<\/jats:italic> mice is devoid of well\u2010defined lymphoid follicles, and the thymus does not show a clear cortical\u2010medullary distinction. The mutant homozygotes are deficient in both humoral and cell\u2010mediated immune functions, and are highly susceptible to infections. They have a reduced level of IgM and severely depressed levels of IgG and IgA in their sera, and do not reject allogeneic skin grafts. However, they have mature T and B cells as determined from their cell surface antigens. The results of bone marrow transplantation experiments suggest a mesenchymal disorder as a possible cause of the lack of lymph nodes and of immunodeficiency in the <jats:italic>aly<\/jats:italic> mouse. The <jats:italic>aly<\/jats:italic> mutant mouse may be a useful animal model of primary immunodeficiency, as are the <jats:italic>nu<\/jats:italic> (nude) and <jats:italic>scid<\/jats:italic> (severe combined immunodeficiency) mice.<\/jats:p>","DOI":"10.1002\/eji.1830240224","type":"journal-article","created":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T20:37:00Z","timestamp":1172781420000},"page":"429-434","source":"Crossref","is-referenced-by-count":243,"title":["A new mutation, <i>aly<\/i>, that induces a generalized lack of lymph nodes accompanied by immunodeficiency in mice"],"prefix":"10.1002","volume":"24","author":[{"given":"Shigeki","family":"Miyawaki","sequence":"first","affiliation":[]},{"given":"Yutaka","family":"Nakamura","sequence":"additional","affiliation":[]},{"given":"Hirotsugu","family":"Suzuka","sequence":"additional","affiliation":[]},{"given":"Masahiro","family":"Koba","sequence":"additional","affiliation":[]},{"given":"Yoshihisa","family":"Shibata","sequence":"additional","affiliation":[]},{"given":"Ryoji","family":"Yasumizu","sequence":"additional","affiliation":[]},{"given":"Susumu","family":"Ikehara","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2005,11,23]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.iy.05.040187.002055"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-1759(89)90388-8"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1258\/002367770781071608"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/304030a0"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(89)90981-1"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(89)90040-6"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.iy.10.040192.003021"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1091900204"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.1989.tb00010.x"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(89)90061-3"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0074-7696(08)61219-X"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(91)90123-B"}],"container-title":["European Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Feji.1830240224","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/eji.1830240224","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T10:19:57Z","timestamp":1698142797000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/eji.1830240224"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,2]]},"references-count":12,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1994,2]]}},"alternative-id":["10.1002\/eji.1830240224"],"URL":"https:\/\/doi.org\/10.1002\/eji.1830240224","archive":["Portico"],"relation":{},"ISSN":["0014-2980","1521-4141"],"issn-type":[{"value":"0014-2980","type":"print"},{"value":"1521-4141","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,2]]}}}