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Transfected ras was shown to be constitutively activated and functionally efficient, since it could be immunoprecipitated in the guanosine triphosphate (GTP)\u2010bound form and it induced transactivation of an AP\u20101 consensus\u2010chloramphenicol acetyltransferase reporter gene. The requirement for ras activation in T cell receptor (TcR) CD3\u2010mediated CD69 induction was also investigated. The expression of a dominant negative c\u2010Ha\u2010<jats:italic>ras<\/jats:italic>\u2010N17 mutant markedly reduced the amount of GTP that could be immunoprecipitated from ras proteins after TcR\/CD3 triggering in Jurkat cells, and concomitantly decreased TcR\/CD3\u2010mediated CD69 induction. These results suggest a central role for ras in TcR\/CD3\u2010mediated CD69 expression in T cells.<\/jats:p>","DOI":"10.1002\/eji.1830240319","type":"journal-article","created":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T20:13:58Z","timestamp":1172780038000},"page":"616-620","source":"Crossref","is-referenced-by-count":108,"title":["Involvement of p21<sup>ras<\/sup> activation in T cell CD69 expression"],"prefix":"10.1002","volume":"24","author":[{"given":"Daniele","family":"d'Ambrosio","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Doreen A.","family":"Cantrell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luigi","family":"Frati","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela","family":"Santoni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Testi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,23]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.164.6.1988"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.168.5.1621"},{"key":"e_1_2_1_4_2","doi-asserted-by":"crossref","first-page":"1854","DOI":"10.4049\/jimmunol.142.6.1854","volume":"142","author":"Testi R.","year":"1989","journal-title":"J. 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