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Here we report that APO\u20101 is constitutively expressed on the vast majority of human thymocytes but down\u2010regulated at a mature stage of thymocyte development (TCR<jats:sup>hi<\/jats:sup>). This stage of development is characterized by CD28<jats:sup>hi<\/jats:sup>, CD44<jats:sup>hi<\/jats:sup>, CD69<jats:sup>hi<\/jats:sup> and up\u2010regulation of Bcl\u20102 protein. We define a new thymocyte subpopulation that expresses high levels of APO\u20101 and intermediate levels of T cell receptor \u03b1\/\u03b2 (TCR<jats:sup>im<\/jats:sup>\/APO\u20101<jats:sup>hi<\/jats:sup>). The TCR<jats:sup>im<\/jats:sup>\/APO\u20101<jats:sup>hi<\/jats:sup> population contains a large fraction of dead cells, suggesting that the APO\u20101 pathway may be involved in negative selection of at least a fraction of thymocytes after intrathymic activation.<\/jats:p>","DOI":"10.1002\/eji.1830240339","type":"journal-article","created":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T20:13:58Z","timestamp":1172780038000},"page":"753-758","source":"Crossref","is-referenced-by-count":47,"title":["Differential expression of APO\u20101 on human thymocytes: Implications for negative selection?"],"prefix":"10.1002","volume":"24","author":[{"given":"Klaus\u2010Michael","family":"Debatin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorothee","family":"S\u00fcss","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter H.","family":"Krammer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,23]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0952-7915(93)90009-H"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.iy.08.040190.002531"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(92)90075-I"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.2125367"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/351150a0"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-2776(08)60822-6"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830210316"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/337181a0"},{"key":"e_1_2_1_10_2","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.4049\/jimmunol.145.5.1364","volume":"145","author":"Nieto M. 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