{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T15:58:33Z","timestamp":1770739113324,"version":"3.49.0"},"reference-count":21,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,12,1]],"date-time":"2005-12-01T00:00:00Z","timestamp":1133395200000},"content-version":"vor","delay-in-days":4262,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[1994,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Mice homozygous for either the <jats:italic>lpr<\/jats:italic> or <jats:italic>gld<\/jats:italic> genes develop phenotypically identical autoimmune disorders. The gene responsible for the pathology in <jats:italic>lpr\/lpr<\/jats:italic> mice encodes the Fas antigen, a protein associated with the induction of programmed cell death. To determine if the defect associated with <jats:italic>gld<\/jats:italic> represents a mutation in the ligand for Fas, we have assessed the ability of lymphoid cells from homozygous <jats:italic>gld\/gld<\/jats:italic> mice to lyse target cells in a Fas\u2010dependent manner. Using an antagonistic antibody to Fas, we demonstrate that activated T cells from normal and <jats:italic>lpr<\/jats:italic> mice are capable of inducing Fas\u2010mediated lysis of tumor target cells. In contrast, activated T cells from <jats:italic>gld\/gld<\/jats:italic> mice fail to induce lysis of tumor targets, although cells from <jats:italic>gld<\/jats:italic> mice are able to lyse specific allogeneic targets following mixed lymphocyte culture. In addition, activated T cells from <jats:italic>gld\/gld<\/jats:italic> homozygous animals are not capable of binding to a Fas.Fc fusion protein at high levels, whereas activated T cells from normal and <jats:italic>lpr\/lpr<\/jats:italic> animals bind Fas.Fc efficiently. These data indicate that mice homozygous for <jats:italic>gld<\/jats:italic> are unable to express a functional ligand for Fas.<\/jats:p>","DOI":"10.1002\/eji.1830240422","type":"journal-article","created":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T20:12:04Z","timestamp":1172779924000},"page":"928-933","source":"Crossref","is-referenced-by-count":97,"title":["<i>gld\/gld<\/i> mice are unable to express a functional ligand for Fas"],"prefix":"10.1002","volume":"24","author":[{"given":"Fred","family":"Ramsdell","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael S.","family":"Seaman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert E.","family":"Miller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teresa W.","family":"Tough","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark R.","family":"Alderson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David H.","family":"Lynch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"crossref","unstructured":"Cohen P. 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