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We examined the effects of the murine recombinant cytokine on the phenotype and activation status of elicited peritoneal macrophages (M\u03d5), concentrating on activities which are known to be modulated by interferon\u2010\u03b3 and IL\u20104. IL\u201013 markedly suppressed nitric oxide release and to a lesser extent secretion of the pro\u2010inflammatory cytokine tumor necrosis factor\u2010\u03b1. However, antimicrobial capacity was not completely jeopardized as the respiratory burst was unaffected, and indeed the enhanced expression of M\u03d5 mannose receptor and major histocompatibility class II, and regulation of sialoadhesin, the M\u03d5 sialic acid\u2010specific receptor involved in hemopoietic and lymphoid interactions, suggest that these cells are not simply deactivated, but primed for an active role in immune and inflammatory responses. These activities closely mimic those of IL\u20104, but mediation of the effects by IL\u20104 was discounted by the use of a neutralizing monoclonal antibody. Thus, IL\u201013, like IL\u20104, is a cytokine which has complex effects on M\u03d5 behavior, inducing activities characteristic of both activation and deactivation.<\/jats:p>","DOI":"10.1002\/eji.1830240630","type":"journal-article","created":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T21:42:08Z","timestamp":1172785328000},"page":"1441-1445","source":"Crossref","is-referenced-by-count":228,"title":["Interleukin\u201013 alters the activation state of murine macrophages <i>in vitro<\/i>: Comparison with interleukin\u20104 and interferon\u2010\u03b3"],"prefix":"10.1002","volume":"24","author":[{"given":"Anthony G.","family":"Doyle","sequence":"first","affiliation":[]},{"given":"Georges","family":"Herbein","sequence":"additional","affiliation":[]},{"given":"Luis J.","family":"Montaner","sequence":"additional","affiliation":[]},{"given":"Adrian J.","family":"Minty","sequence":"additional","affiliation":[]},{"given":"Daniel","family":"Caput","sequence":"additional","affiliation":[]},{"given":"Pascual","family":"Ferrara","sequence":"additional","affiliation":[]},{"given":"Siamon","family":"Gordon","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2005,12]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.136.7.2348"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.166.5.1229"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.170.6.2081"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.10.3803"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/jlb.47.5.475"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.174.5.1209"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830211027"},{"key":"e_1_2_1_9_2","doi-asserted-by":"crossref","first-page":"3578","DOI":"10.4049\/jimmunol.148.11.3578","volume":"148","author":"Oswald I. 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