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Analysis by immuno\u2010fluorescence demonstrated a weak apical expression of CD59 on normal intestinal epithelium, with an increased expression on adenocarcinoma cells. The expression of CD59 was greatest on tumor cells with poor differentiation. The functional activity of CD59 on human adenocarcinoma cells was investigated using the colonic adenocarcinoma cell line HT29, CD59 on HT29 cells was glycosyl\u2010phosphatidylinositol\u2010linked, and had a molecular mass of 19\u201325 kDa. HT29 cells expressed approximately four times more CD59 than leukocytes, and showed a high resistance to antibody\u2010dependent complement\u2010mediated lysis. Blocking of CD59 with divalent antigen\u2010binding F(ab\u2032)<jats:sub>2<\/jats:sub> fragments of the anti\u2010CD59 monoclonal antibody 1F5 resulted in a dose\u2010dependent increase in complement\u2010mediated lysis, suggesting that CD59 may be of importance in protecting colonic adenocarcinoma cells against complement\u2010mediated cytolysis.<\/jats:p>","DOI":"10.1002\/eji.1830240722","type":"journal-article","created":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T21:30:56Z","timestamp":1172784656000},"page":"1597-1603","source":"Crossref","is-referenced-by-count":36,"title":["Expression and function of CD59 on colonic adenocarcinoma cells"],"prefix":"10.1002","volume":"24","author":[{"given":"Line","family":"Bj\u00f8ge","sequence":"first","affiliation":[]},{"given":"Christian A.","family":"Vedeler","sequence":"additional","affiliation":[]},{"given":"Elling","family":"Ulvestad","sequence":"additional","affiliation":[]},{"given":"Roald","family":"Matre","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2005,12]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"crossref","first-page":"184","DOI":"10.4049\/jimmunol.129.1.184","volume":"129","author":"Nicholson\u2010Weller A.","year":"1982","journal-title":"J. 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