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In uCD14 isolated from three different nephrotic patients the cytokine\u2010inducing activity appeared to co\u2010migrate with the 48\u2010kDa polypeptide which upon sequencing had the same N\u2010terminal sequence as native CD14. Treatment of human monocytes and the human astrocytoma cell line U373 with uCD14 resulted in a strong secretion of tumor necrosis factor (TNF) and interleukin\u20106, respectively. The cytokine\u2010inducing activity of the uCD14 preparations was unaffected by the absence of serum. This is in contrast to the activation of human monocytes and U373 cells by lipopolysaccharide (LPS) which is highly dependent on the presence of serum. The cytokine\u2010inducing activity was not affected by LPS\u2010binding protein (LBP) or polyclonal rabbit antibodies against LBP The TNF\u2010inducing activity of uCD14 was also heat labile in contrast to the cytokine\u2010inducing activity of LPS, which was relatively heat resistant. The results suggest that CD14 may exist in at least two forms of which one is involved in cytokine induction.<\/jats:p>","DOI":"10.1002\/eji.1830240809","type":"journal-article","created":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T23:16:16Z","timestamp":1172790976000},"page":"1779-1784","source":"Crossref","is-referenced-by-count":10,"title":["Soluble CD14 from urine copurifies with a potent inducer of cytokines"],"prefix":"10.1002","volume":"24","author":[{"given":"Anders","family":"Sundan","sequence":"first","affiliation":[]},{"given":"Tove","family":"Gullstein\u2010Jahr","sequence":"additional","affiliation":[]},{"given":"Marit","family":"Otterlei","sequence":"additional","affiliation":[]},{"given":"Liv","family":"Ryan","sequence":"additional","affiliation":[]},{"given":"Vladimir","family":"Bazilu","sequence":"additional","affiliation":[]},{"given":"Samuel D.","family":"Wrightu","sequence":"additional","affiliation":[]},{"given":"Terje","family":"Espevik","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2005,12]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.3754653"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198806093182301"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/330662a0"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(87)91728-4"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1698311"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.175.6.1697"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.162.4.1223"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830230140"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830161218"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.141.2.547"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V73.1.284.284"},{"key":"e_1_2_1_13_2","volume-title":"Bacterial endotoxin: recognition and effector mechanism","author":"Bazil V.","year":"1993"},{"key":"e_1_2_1_14_2","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.4049\/jimmunol.135.3.1929","volume":"135","author":"Maliszweski L. 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