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IVIg was found to selectively induce gene transcription and secretion of interleukin\u20101 receptor antagonist (IL\u20101ra) and IL\u20108 in cultures of normal human monocytes. The addition of IVIg to cultures of purified monocytes induced a dose\u2010dependent secretion of IL\u20101ra and IL\u20108 without stimulating the production of IL\u20101\u03b1, IL\u20101\u03b2, tumor necrosis factor\u2010\u03b1 or IL\u20106. The effects of IVIg required both the Fc and F(ab\u2032)<jats:sub>2<\/jats:sub> portions of IgG. IVIg\u2010induced production of IL\u20108 by monocytes was enhanced by lipopolysaccharide (LPS), although LPS inhibited the secretion of IL\u20101ra, suggesting that IVIg and LPS stimulate distinct intracellular pathways in monocytes. Induction of IL\u20101ra and IL\u20108 by IVIg was enhanced in the presence of autologous T lymphocytes. Our observations document the selectivity of the effects of IVIg on the synthesis of cytokines and cytokine antagonists by human monocytes. Induction of IL\u20101ra and IL\u20108 by IVIg may contribute to the anti\u2010inflammatory effects of immunoglobulin therapy in patients with autoimmune and systemic inflammatory disorders.<\/jats:p>","DOI":"10.1002\/eji.1830250521","type":"journal-article","created":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T01:07:04Z","timestamp":1172797624000},"page":"1267-1273","source":"Crossref","is-referenced-by-count":98,"title":["Selective induction of interleukin\u20101 receptor antagonist and interleukin\u20108 in human monocytes by normal polyspecific IgG (intravenous immunoglobulin)"],"prefix":"10.1002","volume":"25","author":[{"given":"Val\u00e9ria Ruiz","family":"de Souza","sequence":"first","affiliation":[]},{"given":"Marie\u2010Paule","family":"Carreno","sequence":"additional","affiliation":[]},{"given":"Srinivas V.","family":"Kaveri","sequence":"additional","affiliation":[]},{"given":"Annick","family":"Ledur","sequence":"additional","affiliation":[]},{"given":"Hoss","family":"Sadeghi","sequence":"additional","affiliation":[]},{"given":"Jean\u2010Marc","family":"Cavaillon","sequence":"additional","affiliation":[]},{"given":"Michel D.","family":"Kazatchkine","sequence":"additional","affiliation":[]},{"given":"Nicole","family":"Haeffner\u2010Cavaillon","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2005,11,17]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199201093260206"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198205273062102"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI114387"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.1994.tb00858.x"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.1994.tb00855.x"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00918683"},{"key":"e_1_2_1_8_2","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1128\/iai.55.3.547-554.1987","volume":"55","author":"Iwata M.","year":"1987","journal-title":"Infect. 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