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However, when these stimuli were administered to thymocyte cultures that were maintained under an atmosphere containing less than 20 ppm oxygen as opposed to one that contained 18.5 % molecular oxygen, cell death was inhibited or abrogated, suggesting that the induction of death by all three different stimuli depend on the presence of molecular oxygen. Studies of the effects of the cysteine analog N\u2010acetyl cysteine (NAC) with normal thymocytes demonstrated that this antioxidant inhibited the induction of death by each of the different stimuli in a manner that paralleled anaerobiosis. Furthermore, studies with thymocytes demonstrated that the induction of <jats:italic>nur77<\/jats:italic>, a gene shown to be involved in thymocyte apoptosis signaled through the TCR or its surrogates, is not inhibited by NAC or dependent upon molecular oxygen. The possible implications for negative selection of NAC\u2010mediated inhibition of TCR\u2010signaled thymocyte cell death was examined in thymic organ culture. Treatment of these cultures with NAC provided significant protection against staphylococcal enterotoxin B\u2010mediated deletion of V\u03b28\u2010expressing thymocytes.<\/jats:p>","DOI":"10.1002\/eji.1830260531","type":"journal-article","created":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T02:03:19Z","timestamp":1172800999000},"page":"1170-1174","source":"Crossref","is-referenced-by-count":23,"title":["The role of oxygen in thymocyte apoptosis"],"prefix":"10.1002","volume":"26","author":[{"given":"Kelly A.","family":"McLaughlin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara A.","family":"Osborne","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard A.","family":"Goldsby","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,6]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.1994.tb00894.x"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/337181a0"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.2125367"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.132.1.38"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/284555a0"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.179.6.1835"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.139.10.3199"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/367281a0"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/362847a0"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.145.12.4037"},{"key":"e_1_2_1_12_2","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.4049\/jimmunol.148.6.1817","volume":"148","author":"Ramakrishnan N.","year":"1992","journal-title":"J. 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