{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T20:44:21Z","timestamp":1771015461133,"version":"3.50.1"},"reference-count":39,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2005,12,6]],"date-time":"2005-12-06T00:00:00Z","timestamp":1133827200000},"content-version":"vor","delay-in-days":3475,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[1996,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Insulin\u2010dependent diabetes mellitus (IDDM) is a T cell\u2010dependent immune\u2010mediated disease. Recently, a novel islet cell antigen (ICA69) recognized by autoantibodies was described. We tested T cell responsiveness to ICA69 in peripheral blood of patients with recent onset IDDM (<jats:italic>n<\/jats:italic> = 46), patients with long\u2010standing IDDM (<jats:italic>n<\/jats:italic> = 44), non\u2010diabetic age\u2010matched, islet cell autoantibody\u2010 and glutamic acid decarboxylase (GAD)65 antibody\u2010negative first\u2010degree relatives of IDDM patients (<jats:italic>n<\/jats:italic> = 15) and rheumatoid arthritis patients (<jats:italic>n<\/jats:italic> = 22). T cell responsiveness was significantly higher in recent onset IDDM patients, compared to IDDM patients post\u2010disease onset, non\u2010diabetic first degree relatives and rheumatoid arthritis patients (<jats:italic>p<\/jats:italic> &lt; 0.001). In responding IDDM patients a significant inverse correlation between T cell and autoantibody responsiveness to ICA69 was observed (<jats:italic>p<\/jats:italic> &lt; 0.0005). Immunogenetic evaluation revealed an association of HLA\u2010DR3 with T cell responsiveness to ICA69 (<jats:italic>p<\/jats:italic> &lt; 0.02) and absence of ICA69\u2010reactive autoantibodies (<jats:italic>p<\/jats:italic> &lt; 0.04). The increased T cell reactivity to ICA69 in the absence of antibody reactivity at onset of IDMM is associated with an HLA class II immune response gene, and therefore suggestive of a genetically controlled selective activation of T helper subsets to a specific autoantigen in humans.<\/jats:p>","DOI":"10.1002\/eji.1830260616","type":"journal-article","created":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T02:02:32Z","timestamp":1172800952000},"page":"1285-1289","source":"Crossref","is-referenced-by-count":46,"title":["HLA\u2010associated inverse correlation between T cell and antibody responsiveness to islet autoantigen in recent\u2010onset insulin\u2010dependent diabetes mellitus"],"prefix":"10.1002","volume":"26","author":[{"given":"Bart O.","family":"Roep","sequence":"first","affiliation":[]},{"given":"Gaby","family":"Duinkerken","sequence":"additional","affiliation":[]},{"given":"Geziena M. 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