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Some of them induce complete T cell responses, <jats:italic>i.e<\/jats:italic>. they act as agonists, whereas others behave as partial agonists or even as antagonists. Here, we analyzed both early (intracellular Ca<jats:sup>2+<\/jats:sup> mobilization), and late (interleukin\u20102 production) signal transduction events induced by a cognate peptide or a corresponding altered peptide ligand using T cell hybridomas expressing or not the CD8 \u03b1 and \u03b2 chains. With a video imaging system, we showed that the intracellular Ca<jats:sup>2+<\/jats:sup> response to an altered peptide ligand induces the appearance of a characteristic sustained intracellular Ca<jats:sup>2+<\/jats:sup> concentration gradient which can be detected shortly after T cell interaction with antigen\u2010presenting cells. We also provide evidence that the same altered peptide ligand can be seen either as an agonist or a partial agonist, depending on the presence of CD8\u03b2 in the CD8 co\u2010receptor dimers expressed at the T cell surface.<\/jats:p>","DOI":"10.1002\/eji.1830261227","type":"journal-article","created":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T01:29:25Z","timestamp":1172798965000},"page":"2999-3007","source":"Crossref","is-referenced-by-count":14,"title":["The CD8\u03b2 polypeptide is required for the recognition of an altered peptide ligand as an agonist"],"prefix":"10.1002","volume":"26","author":[{"given":"Val\u00e9ry","family":"Renard","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00e9r\u00f4me","family":"Delon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Immanuel F.","family":"Luescher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernard","family":"Malissen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Vivier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alain","family":"Trautmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,17]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/1074-7613(95)90074-8"},{"key":"e_1_2_1_3_2","first-page":"113","volume":"314","author":"Germain R. 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