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We show that thymocyte development in these mice can be reconstituted by the introduction of a transgenic T cell receptor (TCR), implying that one function of the IL\u20107R\u03b1 chain is to initiate TCR gene rearrangement. Expression of the recombinase\u2010activating genes <jats:italic>RAG1<\/jats:italic> and <jats:italic>RAG2<\/jats:italic> was greatly reduced in the IL\u20107R\u03b1<jats:sup>\u2010\/\u2010<\/jats:sup> thymuses, and in DN thymocytes from the TCR transgenic IL\u20107R\u03b1<jats:sup>\u2010\/\u2010<\/jats:sup> mice, but was restored in double\u2010positive thymocytes from the TCR transgenic IL\u20107R\u03b1<jats:sup>\u2010\/\u2010<\/jats:sup> mice. These data suggest that the IL\u20107R\u03b1 chain controls RAG expression and initiation of TCR\u03b2 chain VDJ rearrangement in DN cells. In contrast, once cells have progressed beyond the DN stage of development the IL\u20107R\u03b1 chain becomes no longer essential for RAG expression.<\/jats:p>","DOI":"10.1002\/eji.1830270115","type":"journal-article","created":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T03:31:13Z","timestamp":1172806273000},"page":"100-104","source":"Crossref","is-referenced-by-count":35,"title":["A transgenic T cell receptor restores thymocyte differentiation in interleukin\u20107 receptor \u03b1 chain\u2010deficient mice"],"prefix":"10.1002","volume":"27","author":[{"given":"Tessa","family":"Crompton","sequence":"first","affiliation":[]},{"given":"Susan V.","family":"Outram","sequence":"additional","affiliation":[]},{"given":"Jennifer","family":"Buckland","sequence":"additional","affiliation":[]},{"given":"Michael J.","family":"Owen","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2005,12]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/333571a0"},{"key":"e_1_2_1_3_2","first-page":"3168","volume":"74","author":"Conlon P. 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