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Very limited alteration in this repertoire is expected until the immune system is re\u2010challenged by reactivation of latent viruses or by cross\u2010reactive pathogens. Contradicting this view, we show here that the T\u2004cell repertoire specific for two different latent herpes viruses in the peripheral blood displayed significant contemporaneous co\u2010fluctuations of virus\u2010specific CD8<jats:sup>+<\/jats:sup> T\u2004cells. The coordinated responses to two different viruses suggest that the fluctuations within the T\u2004cell repertoire may be driven by sub\u2010clinical viral reactivation or a more generalized \u2018bystander\u2019 effect. The later contention was supported by the observation that, while absolute number of CD3<jats:sup>+<\/jats:sup> T\u2004cells and their subsets and also the cell surface phenotype of antigen\u2010specific T\u2004cells remained relatively constant, a loss of CD62L expression in the total CD8<jats:sup>+<\/jats:sup> T\u2004cell population was coincident with the expansion of tetramer\u2010positive virus\u2010specific T\u2004cells. This study demonstrates that the dynamic process of T\u2004cell expansion and contractions in persistent viral infections is not limited to the acute phase of infection, but also continues during the latent phase of infection.<\/jats:p>","DOI":"10.1002\/eji.200425548","type":"journal-article","created":{"date-parts":[[2004,12,14]],"date-time":"2004-12-14T13:46:34Z","timestamp":1103031994000},"page":"139-149","source":"Crossref","is-referenced-by-count":32,"title":["Contemporaneous fluctuations in T\u2004cell responses to persistent herpes virus infections"],"prefix":"10.1002","volume":"35","author":[{"given":"Tania","family":"Crough","sequence":"first","affiliation":[]},{"given":"Jacqueline\u2004M.","family":"Burrows","sequence":"additional","affiliation":[]},{"given":"Chrysa","family":"Fazou","sequence":"additional","affiliation":[]},{"given":"Susan","family":"Walker","sequence":"additional","affiliation":[]},{"given":"Miles\u2004P.","family":"Davenport","sequence":"additional","affiliation":[]},{"given":"Rajiv","family":"Khanna","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2004,12,16]]},"reference":[{"key":"e_1_2_7_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/369648a0"},{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.183.6.2489"},{"key":"e_1_2_7_3_2","doi-asserted-by":"crossref","first-page":"2627","DOI":"10.1128\/jvi.70.4.2627-2631.1996","article-title":"Human cytotoxic T\u2004cell memory: long\u2010lived responses to vaccinia virus.","volume":"70","author":"Demkowicz W. 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