{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:16:58Z","timestamp":1777594618601,"version":"3.51.4"},"reference-count":51,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,12,12]],"date-time":"2005-12-12T00:00:00Z","timestamp":1134345600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2006,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Streptococcus pneumoniae <\/jats:italic>causes significant morbidity and mortality especially in children. Some pneumococcal protein antigens can protect mice against infection. Little information is available concerning the nature of naturally acquired protective immunity to pneumococci in humans induced by these antigens. This study investigates the relationships between systemic and local antibody production and carriage in children. Children undergoing adenoidectomy (<jats:italic>n<\/jats:italic>=112, ages 2\u201312\u2004years) were studied. Nasopharyngeal swabs were collected for pneumococcal culture. Serum and saliva were assayed for antibodies to several pneumococcal proteins: choline binding protein A (CbpA), pneumolysin (Ply), pneumococcal surface adhesin A (PsaA) and pneumococcal surface protein A (PspA). Adenoidal mononuclear cells (MNC) were cultured with pneumococcal culture supernatants or recombinant proteins. Cell culture supernatants were analyzed for antigen\u2010specific antibodies. Carriage rates fell with age and serum levels of anti\u2010CbpA, Ply and PspA rose. Anti\u2010CbpA and \u2010Ply serum and salivary IgG antibody levels were higher in children who were culture negative than those who were colonized. Antigen stimulation increased respective antigen\u2010specific IgG production by adenoidal MNC and these responses were greater in those who were colonized than in culture\u2010negative children. Antibodies to CbpA and Ply may protect children aged 2\u2004years and older against pneumococcal colonization. Adenoids may be important local induction and effector sites for both mucosal and systemic antibody production to pneumococcal proteins in children.<\/jats:p>","DOI":"10.1002\/eji.200535101","type":"journal-article","created":{"date-parts":[[2005,12,12]],"date-time":"2005-12-12T13:44:15Z","timestamp":1134395055000},"page":"46-57","source":"Crossref","is-referenced-by-count":86,"title":["Serum and mucosal antibody responses to pneumococcal protein antigens in children:relationships with carriage status"],"prefix":"10.1002","volume":"36","author":[{"given":"Qibo","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jolanta","family":"Bernatoniene","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda","family":"Bagrade","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew\u2004J.","family":"Pollard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy\u2004J.","family":"Mitchell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James\u2004C.","family":"Paton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam","family":"Finn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,27]]},"reference":[{"key":"e_1_2_7_1_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.8073278"},{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(01)00063-9"},{"key":"e_1_2_7_3_2","doi-asserted-by":"crossref","first-page":"6533","DOI":"10.1128\/IAI.67.12.6533-6542.1999","article-title":"The pspC gene of Streptococcus pneumoniae encodes a polymorphic protein, PspC, which elicits cross\u2010reactive antibodies to PspA and provides immunity to pneumococcal bacteremia.","volume":"67","author":"Brooks\u2010Walter A.","year":"1999","journal-title":"Infect. 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