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EBF\u20101 has been shown to directly interact with and regulate expression of a set of genes involved in the functional formation of the pre\u2010B cell receptor, but the dramatic phenotype observed in the EBF\u20101\u2010deficient mice suggests that several additional genes are activated by this protein. In order to identify additional target genes for EBF\u20101, we transduced a hematopoietic progenitor cell line, BaF\/3, with an EBF\u20101\u2010encoding retrovirus and investigated the induced gene expression pattern by micro\u2010arrays. This analysis suggested that among others, the CD53 and the carcinoembryonic antigen\u2010related cell adhesion molecule (CEACAM)\u20101 genes both were induced by ectopic expression of EBF\u20101. Identification of the 5\u2032\u2004end of the cDNA enabled the identification of promoter elements with functional binding sites for EBF\u20101 and ability to respond to EBF\u20101 expression in transient transfection assays. These data suggest that CD53 and CEACAM\u20101 are direct genetic targets for EBF\u20101, providing additional information concerning the activity of this crucial transcription factor in hematopoiesis.<\/jats:p>","DOI":"10.1002\/eji.200636642","type":"journal-article","created":{"date-parts":[[2007,4,11]],"date-time":"2007-04-11T16:24:23Z","timestamp":1176308663000},"page":"1365-1376","source":"Crossref","is-referenced-by-count":12,"title":["The CD53 and CEACAM\u20101 genes are genetic targets for early B cell factor"],"prefix":"10.1002","volume":"37","author":[{"given":"Robert","family":"M\u00e5nsson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Lagergren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frida","family":"Hansson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emma","family":"Smith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikael","family":"Sigvardsson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,4,19]]},"reference":[{"key":"e_1_2_7_1_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.181.4.1519"},{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/36122"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.180.5.1955"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20031152"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.288.5470.1439"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80287-3"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(94)90079-5"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(94)90077-9"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(94)90076-0"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/380711a0"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/376263a0"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20032202"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2004.08.006"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20042393"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1991.tb04905.x"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.7.5.760"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80078-3"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.20.10.3640-3654.2000"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80507-5"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.22.24.8539-8551.2002"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M400589200"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.19.1.392"},{"key":"e_1_2_7_23_2","doi-asserted-by":"crossref","first-page":"5453","DOI":"10.4049\/jimmunol.163.10.5453","article-title":"Early B cell factor is an activator of the B\u2004lymphoid kinase promoter in early B cell development.","volume":"163","author":"Akerblad P.","year":"1999","journal-title":"J. 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