{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T07:16:31Z","timestamp":1775978191689,"version":"3.50.1"},"reference-count":55,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2007,11,14]],"date-time":"2007-11-14T00:00:00Z","timestamp":1194998400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2007,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Legionella pneumophila (Lpn)<\/jats:italic> is a ubiquitous Gram\u2010negative bacterium found in aquatic environments and is the causative agent of Legionnaires\u2019 disease, a severe form of pneumonia. We have used <jats:italic>Lpn<\/jats:italic>\u2010permissive A\/J mice as a model to analyze the B cell response upon intravenous (i.v.) and intranasal (i.n.) infection with <jats:italic>Lpn<\/jats:italic>. A strong antibody (Ab) response was observed upon i.v. infection with wild\u2010type (WT) <jats:italic>Lpn<\/jats:italic> and an <jats:italic>icmT<\/jats:italic> mutant strain, which is unable to replicate within permissive host cells. In contrast to i.v. infection, only WT but not <jats:italic>icmT<\/jats:italic> mutant <jats:italic>Lpn<\/jats:italic> was able to induce specific Ab responses upon i.n. infection. After primary i.n. infection with WT <jats:italic>Lpn<\/jats:italic>, a strict compartmentalization of <jats:italic>Lpn<\/jats:italic>\u2010specific Ab isotypes was observed, as IgG was found exclusively systemically, while IgA was detectable only locally in the lung. Regardless of the infection route, isotype switching to IgG and to IgA was strictly dependent on CD4<jats:sup>+<\/jats:sup> T cells, whereas IgM production was completely Th\u2010independent. Finally, we analyzed the protective capacity of the <jats:italic>Lpn<\/jats:italic>\u2010specific Ab response. Actively or passively immunized mice or mice that were infected with opsonized <jats:italic>Lpn<\/jats:italic> had 50\u2013100\u2010fold reduced bacterial titers compared to naive animals, clearly demonstrating the capacity of Ab to protect against infection with <jats:italic>Lpn<\/jats:italic>.<\/jats:p>","DOI":"10.1002\/eji.200737591","type":"journal-article","created":{"date-parts":[[2007,11,14]],"date-time":"2007-11-14T12:23:46Z","timestamp":1195043026000},"page":"3414-3423","source":"Crossref","is-referenced-by-count":38,"title":["Induction and protective role of antibodies in <i>Legionella pneumophila<\/i> infection"],"prefix":"10.1002","volume":"37","author":[{"given":"Nicole","family":"Joller","sequence":"first","affiliation":[]},{"given":"Roman","family":"Sp\u00f6rri","sequence":"additional","affiliation":[]},{"given":"Hubert","family":"Hilbi","sequence":"additional","affiliation":[]},{"given":"Annette","family":"Oxenius","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2007,11,29]]},"reference":[{"key":"e_1_2_8_1_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.71.1.20-28.2005"},{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.72.4.2885-2895.2006"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-2920.2007.01238.x"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.15.3.506-526.2002"},{"key":"e_1_2_8_5_2","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1056\/NEJM197712012972202","article-title":"Legionnaires\u2019 disease: isolation of a bacterium and demonstration of its role in other respiratory disease.","volume":"297","author":"McDade J. 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