{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T21:23:46Z","timestamp":1779312226935,"version":"3.51.4"},"reference-count":70,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2010,6,25]],"date-time":"2010-06-25T00:00:00Z","timestamp":1277424000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2010,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>IL\u20106 is a pleiotropic cytokine involved in the physiology of virtually every organ system. Recent studies have demonstrated that IL\u20106 has a very important role in regulating the balance between IL\u201017\u2010producing Th17 cells and regulatory T cells (Treg). The two T\u2010cell subsets play prominent roles in immune functions: Th17 cell is a key player in the pathogenesis of autoimmune diseases and protection against bacterial infections, while Treg functions to restrain excessive effector T\u2010cell responses. IL\u20106 induces the development of Th17 cells from na\u00efve T cells together with TGF\u2010\u03b2; in contrast, IL\u20106 inhibits TGF\u2010\u03b2\u2010induced Treg differentiation. Dysregulation or overproduction of IL\u20106 leads to autoimmune diseases such as multiple sclerosis (MS) and rheumatoid arthritis (RA), in which Th17 cells are considered to be the primary cause of pathology. Given the critical role of IL\u20106 in altering the balance between Treg and Th17 cells, controlling IL\u20106 activities is potentially an effective approach in the treatment of various autoimmune and inflammatory diseases. Here, we review the role of IL\u20106 in regulating Th17\/Treg balance and describe the critical functions of IL\u20106 and Th17 in immunity and immune\u2010pathology.<\/jats:p>","DOI":"10.1002\/eji.201040391","type":"journal-article","created":{"date-parts":[[2010,6,25]],"date-time":"2010-06-25T15:06:10Z","timestamp":1277478370000},"page":"1830-1835","source":"Crossref","is-referenced-by-count":1360,"title":["IL\u20106: Regulator of Treg\/Th17 balance"],"prefix":"10.1002","volume":"40","author":[{"given":"Akihiro","family":"Kimura","sequence":"first","affiliation":[]},{"given":"Tadamitsu","family":"Kishimoto","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2010,6,25]]},"reference":[{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.8097338"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.178.2.567"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20040590"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature01202"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(88)91308-4"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.164.5.2759"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2004.08.018"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20041257"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(02)00391-6"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature06764"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20030152"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1818"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature04753"},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature04754"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2006.01.001"},{"key":"e_1_2_9_17_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-05-155846"},{"key":"e_1_2_9_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60454-7"},{"key":"e_1_2_9_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/324073a0"},{"key":"e_1_2_9_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/332083a0"},{"key":"e_1_2_9_21_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.1.232"},{"key":"e_1_2_9_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(87)80344-7"},{"key":"e_1_2_9_23_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.84.20.7251"},{"key":"e_1_2_9_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/368339a0"},{"key":"e_1_2_9_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(90)90411-7"},{"key":"e_1_2_9_26_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1411569"},{"key":"e_1_2_9_27_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.8272873"},{"key":"e_1_2_9_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-9525(00)89000-9"},{"key":"e_1_2_9_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2004.08.018"},{"key":"e_1_2_9_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1359-6101(03)00002-9"},{"key":"e_1_2_9_31_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.194.4.519"},{"key":"e_1_2_9_32_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.52.1.65"},{"key":"e_1_2_9_33_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.177.1.566"},{"key":"e_1_2_9_34_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.171.11.6173"},{"key":"e_1_2_9_35_2","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2008.070690"},{"key":"e_1_2_9_36_2","doi-asserted-by":"publisher","DOI":"10.1191\/096120300678828703"},{"key":"e_1_2_9_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellimm.2005.11.002"},{"key":"e_1_2_9_38_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni1254"},{"key":"e_1_2_9_39_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20041257"},{"key":"e_1_2_9_40_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.168.11.5699"},{"key":"e_1_2_9_41_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature05970"},{"key":"e_1_2_9_42_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200939487"},{"key":"e_1_2_9_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.07.035"},{"key":"e_1_2_9_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2007.11.016"},{"key":"e_1_2_9_45_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0801162"},{"key":"e_1_2_9_46_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.178.8.4901"},{"key":"e_1_2_9_47_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0705268104"},{"key":"e_1_2_9_48_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni1375"},{"key":"e_1_2_9_49_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.177.3.1416"},{"key":"e_1_2_9_50_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni1376"},{"key":"e_1_2_9_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2007.02.009"},{"key":"e_1_2_9_52_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni1500"},{"key":"e_1_2_9_53_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20052222"},{"key":"e_1_2_9_54_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0804231105"},{"key":"e_1_2_9_55_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1145697"},{"key":"e_1_2_9_56_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature06880"},{"key":"e_1_2_9_57_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature06881"},{"key":"e_1_2_9_58_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-2896.2006.00427.x"},{"key":"e_1_2_9_59_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20030152"},{"key":"e_1_2_9_60_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm0804-801"},{"key":"e_1_2_9_61_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-2896.2005.00280.x"},{"key":"e_1_2_9_62_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-2896.2006.00420.x"},{"key":"e_1_2_9_63_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature06878"},{"key":"e_1_2_9_64_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.24126"},{"key":"e_1_2_9_65_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0802218105"},{"key":"e_1_2_9_66_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-12-4602"},{"key":"e_1_2_9_67_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2004.01.012"},{"key":"e_1_2_9_68_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.27221"},{"key":"e_1_2_9_69_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.20303"},{"key":"e_1_2_9_70_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI5703"},{"key":"e_1_2_9_71_2","doi-asserted-by":"publisher","DOI":"10.1186\/ar1916"}],"container-title":["European Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Feji.201040391","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/eji.201040391","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T14:06:37Z","timestamp":1697465197000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/eji.201040391"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,6,25]]},"references-count":70,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2010,7]]}},"alternative-id":["10.1002\/eji.201040391"],"URL":"https:\/\/doi.org\/10.1002\/eji.201040391","archive":["Portico"],"relation":{},"ISSN":["0014-2980","1521-4141"],"issn-type":[{"value":"0014-2980","type":"print"},{"value":"1521-4141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,6,25]]}}}