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This review covers the use of various CE separation modes, capillary coatings, MS analyzers, sample preparation techniques, and data analysis methods used in CE\u2010MS for metabolomics. The applicability of CE\u2010MS in metabolomics research is illustrated by giving examples of the analysis of bacterial extracts, plant extracts, urine, plasma, and cerebrospinal fluid samples. The relevant CE\u2010MS metabolomics studies published between 2000 and 2008 are presented in tabular form, including information on sample type and pretreatment and MS detection mode. Future developments with regard to the use of alternative ionization techniques, the use of coupled separation systems and the potential of microchip CE systems for metabolomics are discussed.<\/jats:p>","DOI":"10.1002\/elps.200800512","type":"journal-article","created":{"date-parts":[[2008,12,23]],"date-time":"2008-12-23T01:42:05Z","timestamp":1229996525000},"page":"276-291","source":"Crossref","is-referenced-by-count":257,"title":["CE\u2010MS in metabolomics"],"prefix":"10.1002","volume":"30","author":[{"given":"Rawi","family":"Ramautar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Govert W.","family":"Somsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerhardus J.","family":"de 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