{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T21:40:20Z","timestamp":1766266820891},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2006,7,14]],"date-time":"2006-07-14T00:00:00Z","timestamp":1152835200000},"content-version":"vor","delay-in-days":9325,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Environ. mutagen"],"published-print":{"date-parts":[[1981,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Gamma\u2010irradiation was effectively employed to sterilize rat liver postmito\u2010chondrial supernant (PMS), which is required for the metabolic activation of soots and soot\u2010derived polycyclic aromatic hydrocarbons to mutagens. When a known number of Bacillus subtilis spores were added to the PMS and gammairradiated at \u221280\u00b0 C, a 2\u2010Mrad dose resulted in a 7.5 log kill of the spores. A dose of 3 Mrads was selected as a sufficient effective sterilizing dose and had no significant effect upon the ability of gamma\u2010irradiated PMS to metabolically activate diesel soot and two diesel soot components, benzo(a)pyrene and fluoranthene to mutagens in a Salmonella typhimurium 8\u2010azaguanine resistance forward mutation assay. Three Mrads of gamma\u2010irradiation also had no effect upon the ability of PMS to activate benzo[a]pyrene to a mutagen for the human lymphoblasts. However, gamma\u2010irradiation did reduce the ability of PMS to activate dimethylnitrosamine to a mutagen for S typhimurium.<\/jats:p>","DOI":"10.1002\/em.2860030508","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T21:52:45Z","timestamp":1172008365000},"page":"565-573","source":"Crossref","is-referenced-by-count":5,"title":["Radiosterilization of rat liver microsome containing postmitochondrial supernatant for mutation assays"],"prefix":"10.1002","volume":"3","author":[{"given":"Thomas R.","family":"Barfknecht","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara M.","family":"Andon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Walter W.","family":"Bishop","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William G.","family":"Thilly","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,14]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.70.8.2281"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1161(75)90046-1"},{"key":"e_1_2_1_4_1","first-page":"283","volume-title":"Progress in Industrial Microbiology","author":"Bridges BA","year":"1964"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/apm.1964.60.2.253"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/apm.1964.62.3.448"},{"key":"e_1_2_1_7_1","first-page":"245","volume-title":"Chemical Carcinogens","author":"Dipple A","year":"1976"},{"key":"e_1_2_1_8_1","first-page":"249","article-title":"Biochemical aspects of chemical carcinogenesis","volume":"65","author":"Gielen JE","year":"1978","journal-title":"Bull Cancer"},{"key":"e_1_2_1_9_1","first-page":"387","volume-title":"Radiosterilization of Medical Products 1974","author":"Gopal NGS","year":"1975"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bi.44.070175.000455"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0020-708X(59)90099-7"},{"key":"e_1_2_1_12_1","unstructured":"KadenDA AndonBM LiLL HitesRA ThillyWG(1980):Mutagenicity of kerosene soot diesel soot and air particulates to Salmonella typhimurium. 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