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In the present study, we have cloned and sequenced the breakpoint junction from a second patient. The breakpoint on chromosome 14 occurs within a switch region upstream of the immunoglobulin heavy chain C\u03b11 sequence. We detected a 2.1\u20132.3 kb transcript on Northern blots using a probe from chromosome 19 adjacent to this breakpoint. S<jats:sub>1<\/jats:sub> nuclease protection experiments showed that transcription of the gene proceeds in a direction away from the breakpoint junction. This gene (for which we propose the name <jats:italic>BCL3<\/jats:italic>) may contribute to the malignant development of B\u2010lymphocytes following the chromosome translocation. If so, it is the first protooncogene identified whose activation is principally associated with CLL.<\/jats:p>","DOI":"10.1002\/gcc.2870010310","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T22:38:25Z","timestamp":1172097505000},"page":"247-255","source":"Crossref","is-referenced-by-count":52,"title":["Identification of a transcriptional unit adjacent to the breakpoint in the 14;19 translocation of chronic lymphocytic leukemia"],"prefix":"10.1002","volume":"1","author":[{"given":"Timothy W.","family":"McKeithan","sequence":"first","affiliation":[]},{"given":"Hitoshi","family":"Ohno","sequence":"additional","affiliation":[]},{"given":"Manuel 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