{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T00:06:06Z","timestamp":1761523566223},"reference-count":19,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,7,14]],"date-time":"2006-07-14T00:00:00Z","timestamp":1152835200000},"content-version":"vor","delay-in-days":5857,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Chromosomes &amp; Cancer"],"published-print":{"date-parts":[[1990,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Mutations at codon 12, 13, and 61 of the <jats:italic>HRAS, KRAS<\/jats:italic>, and <jats:italic>NRAS<\/jats:italic> genes were evaluated in 99 cases of pediatric acute myeloid leukemia (AML) using oligonucleotide hybridization to polymerase chain reacted derived products. Twenty\u2010four mutations were identified in the <jats:italic>NRAS<\/jats:italic> gene, 13 in the <jats:italic>KRAS<\/jats:italic> gene, and none in the <jats:italic>HRAS<\/jats:italic> gene. The mutations occurred in a broad spectrum of cases, and there was no specific association of <jats:italic>RAS<\/jats:italic> gene mutations with patient subsets defined on the basis of clinical or hematologic features. These data demonstrate that <jats:italic>RAS<\/jats:italic> gene mutations are at least as common in childhood AML as in adult AML and suggest that <jats:italic>RAS<\/jats:italic> gene mutations play a role in myeloid neoplasia in both age groups.<\/jats:p>","DOI":"10.1002\/gcc.2870020212","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T22:52:36Z","timestamp":1172098356000},"page":"159-162","source":"Crossref","is-referenced-by-count":35,"title":["<i>RAS<\/i> gene mutations in childhood acute myeloid leukemia: A pediatric oncology group study"],"prefix":"10.1002","volume":"2","author":[{"given":"Bert","family":"Vogelstein","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Curt I.","family":"Civin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonette C.","family":"Preisinger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey P.","family":"Krischer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip","family":"Steuber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Ravindranath","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Howard","family":"Weinstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Ellferich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes","family":"Bos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,14]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bi.56.070187.004023"},{"key":"e_1_2_1_3_1","first-page":"247","article-title":"Acute myeloid leukemia: Analysis of ras gene mutations and clonality defined by polymorphic X\u2010linked loci","volume":"3","author":"Bartram CR","year":"1989","journal-title":"Leukemia"},{"key":"e_1_2_1_4_1","first-page":"4682","article-title":"Ras oncogenes in human cancer","volume":"49","author":"Bos JL","year":"1989","journal-title":"Cancer Res"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V69.4.1237.1237"},{"key":"e_1_2_1_6_1","unstructured":"BoyumA(1968)Separation of mononuclear cells and granulocytes from human blood: Isolation of mononuclear cells by one centrifugation and of granulocytes by combining centrifugation and sedimentation at 1 g. 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