{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T15:11:15Z","timestamp":1770477075290,"version":"3.49.0"},"reference-count":21,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,7,14]],"date-time":"2006-07-14T00:00:00Z","timestamp":1152835200000},"content-version":"vor","delay-in-days":5795,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Chromosomes &amp; Cancer"],"published-print":{"date-parts":[[1990,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The t(10;14)(q24;q11) translocation is a non\u2010random chromosome change seen in the leukemic cells of 5\u201310% of patients with T\u2010cell acute lymphoblastic leukemia (T\u2010ALL). Recent studies support the hypothesis that the translocation occurs in the course of aberrant physiological recombination and results in the juxtaposition of a T\u2010cell receptor (<jats:italic>TCR<\/jats:italic>) gene in 14q11 with a putative oncogene, <jats:italic>TCL3<\/jats:italic>, in 10q24. We cloned and sequenced the translocation breakpoints on both derivative 10q+ and 14q\u2013 chromosomes from a patient with t(10;14)(q24;q11) T\u2010ALL. Two distinct diversity segments of <jats:italic>TCRD<\/jats:italic>, D\u03b42 and D\u03b43, were identified at the two translocation breakpoints on chromosome 14. The 9.5 kb DNA that separates these two subunits in the germline was deleted, possibly in the course of a D\u2010D joining event. The two chromosome 10 breakpoints were 10 nucleotides apart and occurred in the immediate vicinity of a pseudo\u2010heptamer signal motif. N\u2010region addition is also evident at the breakpoint on the derivative chromosome 10. Our observations strongly suggest that the <jats:italic>IG\/TCR<\/jats:italic> recombinase normally involved in V\u2010(D)\u2010J joining was involved in the process of the t(10;14)(q24;q11) translocation.<\/jats:p>","DOI":"10.1002\/gcc.2870020309","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T22:52:20Z","timestamp":1172098340000},"page":"217-222","source":"Crossref","is-referenced-by-count":20,"title":["Molecular characterization of the t(10;14) translocation breakpoints in T\u2010cell acute lymphoblastic leukemia: Further evidence for illegitimate physiological recombination"],"prefix":"10.1002","volume":"2","author":[{"given":"Ming","family":"Lu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ian","family":"Dub\u00e9","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susana","family":"Raimondi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Carroll","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Minden","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Sutherland","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,14]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1988.tb02993.x"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1976.tb03563.x"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.322279"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.2870010303"},{"key":"e_1_2_1_6_1","doi-asserted-by":"crossref","first-page":"2621","DOI":"10.1002\/j.1460-2075.1989.tb08402.x","article-title":"Alternating purine\u2010pyrimidine tracts may promote chromosomal translocations seen in a variety of human lymphoid tumors","volume":"8","author":"Bochm T","year":"1989","journal-title":"EMBO J"},{"key":"e_1_2_1_7_1","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1182\/blood.V67.4.1181.1181","article-title":"A new translocation, t(10;14)(q24;q11), in T\u2010cell neoplasia","volume":"67","author":"Dub\u00e9 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of a patient with T\u2010cell acute lymphoblastic leukemia","volume":"31","author":"Park JK","year":"1989","journal-title":"Blood [Suppl]"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.81.14.4363"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.74.12.5463"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2836(75)80083-0"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.85.16.6097"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.87.8.3161"}],"container-title":["Genes, Chromosomes and 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