{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T15:01:47Z","timestamp":1770822107233,"version":"3.50.1"},"reference-count":37,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,7,14]],"date-time":"2006-07-14T00:00:00Z","timestamp":1152835200000},"content-version":"vor","delay-in-days":5553,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Chromosomes &amp; Cancer"],"published-print":{"date-parts":[[1991,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cytogenetic abnormalities in non\u2010Hodgkin's Lymphoma (NHL) provide a model system for the analysis of the role of multiple genomic aberrations in human malignancy. In order to define correlations with histology, tumor evolution, and the effects of genotoxic exposure, Cytogenetic analysis was performed on 434 specimens of NHL derived from 423 patients consecutively ascertained over a 5\u2010year period (1984\u20131989). Six recurring translocations (RT) were observed: t(14;18)(q32;q21), t(8;14)(q24;q32), t(11;14)(q13;q32), t(3;22)(q27;11), t(2;5)(p23;q35), and t(1;6)(q21;q25). No translocation was specific to a single histologic subtype. Other structural chromosome abnormalities were analyzed according to break site; groups of related breaks were considered together for statistical analysis. Recurring other structural and numerical aberrations (ROA) encountered in &gt;10% of specimens included rearrangements with breaks at bands 1p32\u201336, 1q21\u201323, 6q21\u201325, and trisomies of chromosomes 7 and 12. ROA with one of these breaks or numerical abnormalities were the sole abnormalities in at least two cases. Correlations were observed among ROA and between ROA and histologic subtypes. Trisomy 7, breaks at 1q21\u201323, 1p32\u201036, 6q21\u201325, and 7q32 were associated with t(14;18); trisomy 18 was associated with trisomy 3; and structural abnormalities of chromosome 17 were associated with breaks at 1p32\u201036 and 6q21\u201325. Trisomy 7 and trisomy 12 were more frequent in t( 14;18)\u2010bearing intermediate to high grade tumors compared to low grade tumors. Trisomy 12 and breaks at band 1p22 were associated with large cell diffuse lymphomas. Incidence rates of reciprocal translocations, ROA, and measures of karyotypic complexity, including number of breakpoints and marker chromosomes were compared in pretreatment and posttreatment samples. Karyotypic complexity was greater in the posttreatment samples, reflecting an increased frequency of nonrecurring and low incidence aberrations. These results better define the association of genomic aberrations and tumori\u2010genesis, histologic transformation, and tumor progression.<\/jats:p>","DOI":"10.1002\/gcc.2870030304","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T22:50:25Z","timestamp":1172098225000},"page":"189-201","source":"Crossref","is-referenced-by-count":130,"title":["Cytogenetic analysis of 434 consecutively ascertained specimens of non\u2010Hodgkin's lymphoma: Correlations between recurrent aberrations, histology, and exposure to cytotoxic treatment"],"prefix":"10.1002","volume":"3","author":[{"given":"Kenneth","family":"Offit","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suresh C.","family":"Jhanwar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"Ladanyi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel A.","family":"Filippa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. S. K.","family":"Chaganti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,14]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"1091","article-title":"Translocation (2;9) associated with poor outcome of childhood lymphoblastic lymphoma","volume":"8","author":"Arenson E","year":"1989","journal-title":"Proc Annu Meet Am Soc Clin Oncol"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/80.8.576"},{"key":"e_1_2_1_4_1","volume-title":"Statistical Methods in Medical Research","author":"Armitage P","year":"1977"},{"key":"e_1_2_1_5_1","first-page":"1","article-title":"Spontaneous and induced changes in cell populations in heavily irradiated mice","volume":"2","author":"Barnes DWH","year":"1959","journal-title":"Prog Nuclear Energy Sci"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(88)90161-6"},{"key":"e_1_2_1_7_1","first-page":"2975","article-title":"Nonrandom chromosome abnormalities in lymphoma","volume":"43","author":"Bloomfield CD","year":"1983","journal-title":"Cancer Res"},{"key":"e_1_2_1_8_1","first-page":"5557","article-title":"Frequent nonrandom chromosome abnormalities in 27 patients with untreated large cell lymphoma and immunoblastic lymphoma","volume":"48","author":"Cabanillas F","year":"1988","journal-title":"Cancer Res"},{"key":"e_1_2_1_9_1","first-page":"415","article-title":"Utilization of monoclonal antibody L26 in the identification and confirmation of B cell lymphomas; a sensitive and specific marker applicable to formalin B5 fixed paraffin embedded tissues","volume":"129","author":"Cartun RW","year":"1987","journal-title":"Am J Pathol"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000132436"},{"key":"e_1_2_1_11_1","first-page":"33","article-title":"Specific translocations in non\u2010Hodgkin's lymphoma: Incidence, molecular detection, and histological and clinical correlations","volume":"7","author":"Chaganti RSK","year":"1989","journal-title":"Cancer Cells"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V65.1.1.1"},{"key":"e_1_2_1_13_1","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.1182\/blood.V70.5.1554.1554","article-title":"Correlation of chromosome abnormalities with histologic and immunologie characteristics in non\u2010Hodgkin's lymphoma and adult T cell leukemia\u2010lymphoma","volume":"70","author":"Fifth International Workshop on Chromosomes in Leukemia\u2010Lymphoma","year":"1987","journal-title":"Blood"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.2870020106"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910220105"},{"key":"e_1_2_1_16_1","volume-title":"Cancer Cytogenetics","author":"Heim S","year":"1987"},{"key":"e_1_2_1_17_1","first-page":"53","volume-title":"Advances in Viral Oncology","author":"Heim S","year":"1987"},{"key":"e_1_2_1_18_1","volume-title":"An International System for Human Cytogenetic Nomenclature","author":"ISCN","year":"1985"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910300304"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910320606"},{"key":"e_1_2_1_21_1","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1182\/blood.V73.3.806.806","article-title":"A novel translocation, t(2;5)(p23;q35) in childhood phagocytic large T\u2010cell lymphoma mimicking malignant histiocytosis","volume":"73","author":"Kaneko Y","year":"1989","journal-title":"Blood"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V69.1.97.97"},{"key":"e_1_2_1_23_1","first-page":"866","article-title":"The t(2;5)(p23;q35): A recurring chromosomal abnormality in Ki\u20101 positive anaplastic large cell lymphoma","volume":"12","author":"Le Beau MM","year":"1989","journal-title":"Leukemia"},{"key":"e_1_2_1_24_1","first-page":"6481","article-title":"Correlations between immunological phenotype and karyotype in malignant lymphoma","volume":"46","author":"Hurd DD","year":"1986","journal-title":"Cancer Res"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-108-1-14"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.2870010403"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198605153142016"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19820515)49:10<2112::AID-CNCR2820491024>3.0.CO;2-2"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.39.4.399"},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(89)90078-2"},{"key":"e_1_2_1_31_1","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1182\/blood.V70.2.444.444","article-title":"Intermediate to high grade histology of lymphomas carrying t(14;18) is associated with additional non\u2010random chromosome changes","volume":"70","author":"Richardson ME","year":"1987","journal-title":"Blood"},{"key":"e_1_2_1_32_1","doi-asserted-by":"crossref","first-page":"1841","DOI":"10.1182\/blood.V75.9.1841.1841","article-title":"Chromosomal abnormalities in untreated patients with non\u2010Hodgkin's lymphoma: associations with histology, clinical characteristics, and treatment outcome","volume":"75","author":"Schouten HC","year":"1990","journal-title":"Blood"},{"key":"e_1_2_1_33_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V67.3.650.650"},{"key":"e_1_2_1_34_1","first-page":"412","article-title":"Coiorectal cancer genes","volume":"342","author":"Soloman E","year":"1990","journal-title":"Science"},{"key":"e_1_2_1_35_1","first-page":"2890","article-title":"Cytogenetic, flow cytometric and ultrastructural studies of 29 nonfamilial renal cell carcinomas","volume":"48","author":"Wolman SR","year":"1988","journal-title":"Cancer Res"},{"key":"e_1_2_1_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(84)90084-0"},{"key":"e_1_2_1_37_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198701083160204"},{"key":"e_1_2_1_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910170108"}],"container-title":["Genes, Chromosomes and Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fgcc.2870030304","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/gcc.2870030304","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T07:47:09Z","timestamp":1698047229000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/gcc.2870030304"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,5]]},"references-count":37,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1991,5]]}},"alternative-id":["10.1002\/gcc.2870030304"],"URL":"https:\/\/doi.org\/10.1002\/gcc.2870030304","archive":["Portico"],"relation":{},"ISSN":["1045-2257","1098-2264"],"issn-type":[{"value":"1045-2257","type":"print"},{"value":"1098-2264","type":"electronic"}],"subject":[],"published":{"date-parts":[[1991,5]]}}}