{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T22:19:25Z","timestamp":1772749165383,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2006,7,14]],"date-time":"2006-07-14T00:00:00Z","timestamp":1152835200000},"content-version":"vor","delay-in-days":5430,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Chromosomes &amp; Cancer"],"published-print":{"date-parts":[[1991,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A series of 105 patients with acute promyelocytic leukemia (APL) has been cytogenetically investigated at the Department of Hematology of the Saint\u2010Louis Hospital (Paris) between 1977 and 1990. Sixty\u2010two patients were examined at diagnosis, 32 in relapse, and 11 both at diagnosis and in relapse. The typical t( 15; 17)(q22;q 12) or variants of this translocation were observed in all but four patients. The t(15;17) was the only change in 47 cases at diagnosis and in 21 examined in relapse. The most frequent secondary change was trisomy 8 (17% at diagnosis). More or less complex chromosomal abnormalities in addition to t(15;17) were present in six patients at diagnosis, and in 17 patients in relapse. Rearrangements of 2q35\u2010q37 and del(11p) were observed only in relapse and may thus be nonrandom secondary changes. Cytogenetic studies performed on 19 patients treated with all\u2010trans retinoic acid did not indicate that this treatment induces chromosomal abnormalities.<\/jats:p>","DOI":"10.1002\/gcc.2870030503","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T22:50:12Z","timestamp":1172098212000},"page":"332-337","source":"Crossref","is-referenced-by-count":69,"title":["Cytogenetic Studies in Acute Promyelocytic Leukemia: A Survey of Secondary Chromosomal Abnormalities"],"prefix":"10.1002","volume":"3","author":[{"given":"Roland","family":"Berger","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maryvonne Le","family":"Coniat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josette","family":"Derr\u00e9","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dani\u00e8le","family":"Vecchione","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Jonveaux","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,14]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1976.tb03563.x"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1980.tb01195.x"},{"key":"e_1_2_1_4_1","first-page":"177","article-title":"Une nouvelle vari\u00e9t\u00e9 de leuc\u00e9mie aigu\u00eb non promy\u00e9locytaire avec trans location t(15;17)","volume":"288","author":"Berger R","year":"1979","journal-title":"CR Acad Sc (Paris)"},{"key":"e_1_2_1_5_1","first-page":"1557","article-title":"Absence d'anomalie chromoso mique et leuc\u00e9mies aigu\u00ebs: Relations avec les cellules m\u00e9dullaires normales","volume":"290","author":"Berger R","year":"1980","journal-title":"CR Acad Sc (Paris)"},{"key":"e_1_2_1_6_1","first-page":"27","article-title":"t(15;17) translocation in acute promyelocytic leukemia (M3) and cytological \u201cMS\u2010variant\u201d","volume":"23","author":"Berger R","year":"1981","journal-title":"Nouv Rev Fr H\u00e9matol"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0145-2126(83)90011-5"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(87)90026-4"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(88)90161-6"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2218500"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V76.9.1704.1704"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/347558a0"},{"key":"e_1_2_1_13_1","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1182\/blood.V55.2.253.253","article-title":"\u201cMi crogranular\u201d acute promyelocytic leukemia: A distinct clinical, ul trastructural, and Cytogenetic entity","volume":"55","author":"Golomb HM","year":"1980","journal-title":"Blood"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(90)90043-A"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00296446"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(86)90025-7"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V72.2.567.567"},{"key":"e_1_2_1_18_1","volume-title":"An International System for Human Cytogenetic Nomencla ture","author":"ISCN","year":"1985"},{"key":"e_1_2_1_18_2","volume-title":"Birth Defects: Original Article Series","year":"1985"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(86)90617-0"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(84)90994-X"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(85)90190-6"},{"key":"e_1_2_1_22_1","first-page":"133","article-title":"Chromosome studies in acute promyelocytic leukemia. 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