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We also define a new hot\u2010spot region which is observed predominantly in lung tumors. Analysis of the mutational events suggests the direct involvement of environmental carcinogens in lung tumors and hepatocarcinomas, and spontaneous mutagenesis generating essentially CpG transitions in most of the remaining ones. Furthermore, we demonstrate in this work that the <jats:italic>TP53<\/jats:italic> gene is an informative model with which to study the molecular mechanisms of mutagenesis in the human genome.<\/jats:p>","DOI":"10.1002\/gcc.2870040102","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T23:13:41Z","timestamp":1172099621000},"page":"1-15","source":"Crossref","is-referenced-by-count":360,"title":["TP53 tumor suppressor gene: A model for investigating human mutagenesis"],"prefix":"10.1002","volume":"4","author":[{"given":"Claude Caron De","family":"Fromentel","sequence":"first","affiliation":[]},{"given":"Thierry","family":"Soussi","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2006,7,14]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI115234"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2649981"},{"key":"e_1_2_1_4_1","first-page":"7717","article-title":"p53 gene mutations occur in combination with 17p allelic deletions as late events in colorectal tumorigenesis","volume":"50","author":"Baker SJ","year":"1990","journal-title":"Cancer Res"},{"key":"e_1_2_1_5_1","first-page":"893","article-title":"Genetic and immunochemical analysis of mutant p53 in human breast cancer cell lines","volume":"5","author":"Bartek J","year":"1990","journal-title":"Oncogene"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/350429a0"},{"key":"e_1_2_1_7_1","doi-asserted-by":"crossref","unstructured":"Caron de FromentelC PadkelC ChapusA BaneyC MayP SoussiT(1992)Rainbow trout p53: cDNA cloning and biochemical characterization. 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